The effect of transcranial direct current stimulation on upper limb motor function in stroke patients

Not Applicable

Recruiting

• Conditions: unilateral ischemic stroke.; Cerebral infarction, unspecified; 163.9

• Registration Number: IRCT20140222016680N9
• Lead Sponsor: Iran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 21 November 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

Having a first unilateral ischemic stroke as confirmed by the MRI or CT-Scan
At least 6 months have passed since the unilateral stroke
Having the ability to walk for at least 10 meter (with or without cane)
Having motor dysfunction in upper limb with a degree of recovery equal or more than 4 according to the recovery stages of Brunnstrom
Having a score equal or above 26 in the Montreal Cognitive Assessment

Exclusion Criteria

Having moderate to severe depression (a score of 19 or higher on the Beck depression scale)
Received Botox in the previous 6 months (to enter the study, patients must not have received Botox in the past six months)
Having a contracture in the wrist and fingers of the affected side
Having other neurological disorders such as Parkinson, Multiple Sclerosis and etc.
Having a thalamic stroke or central pain syndrome (Dejerine Roussy Syndrome)
Pain in the affected shoulder (having a score of less than 12 based on the Pain Assessment section of the Fugle-Meyer assessment of the upper extremity)
Using drugs that affect the central nervous system
Having pace maker or other stimulation or ferromagnetic implants
Having a history of Seizures in the last two years and taking anticonvulsant drugs during one month before the enrollment in the current study
Pregnancy
unwillingness and lack of cooperation to continue the treatment
Having serious and persistent skin complications or sleep and concentration disorders due to stimulation with tDCs
Not completing the treatment period or occurrence of an accident that affects the motor function or brain activity

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Electroencephalography parameters include Absolute power and Relative power and Average frequency within each frequency subband (delta, theta, alpha, beta and gamma). Timepoint: before treatment, after treatment (15th session), and 3 months later. Method of measurement: EEG recording.

Secondary Outcome Measures

Name	Time	Method
pper limb motor function ability by the Wolf Motor Function Test. Timepoint: before treatment, after treatment (15th session), and 3 months later. Method of measurement: Wolf Motor Function Test.;Upper limb motor function by the upper extremity part of the Fugl-Meyer Assessment. Timepoint: before treatment, after treatment (15th session), and 3 months later. Method of measurement: Upper Extremity part of the Fugl-Meyer Assessment.;Patient's ability to handle objects of different sizes, weights and shapes. Timepoint: before treatment, after treatment (15th session), and 3 months later. Method of measurement: Action Research Arm Test.