The Analysis of Immuno-Nutrition Index in Advanced Gastric Cancer Receiving Preoperative Treatments: Observational Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- Pathological response
研究概览
简要总结
Based on multiple studies, the immune (systemic inflammation) and nutrition index were correlated with short- and long-term prognosis for gastric cancer. With the increasing application of preoperative treatments (chemotherapy and chemoradiotherapy), the issues concerning how are the immuno-nutrition index be altered under the effects of perioperative treatments and what are the clinical values of these index should be clarified.
详细描述
The immune (systemic inflammation) index includes:
NLR (Neutrophil-to-Lymphocyte Ratio); PLR (Platelet-to-Lymphocyte Ratio); SII (Systemic Immune-Inflammation Index); GPS (Glasgow Prognostic Score); mGPS (modified Glasgow Prognostic Score); PI (Prognostic Index);
The nutrition index includes:
NRS2002; PNI (Prognostic Nutrition Index);
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed adenocarcinoma
- •Received neoadjuvant (preoperative) chemotherapy or chemoradiotherapy
- •Diagnosed clinical advanced gastric cancer or esophagogastric cancer
排除标准
- •Lack of immuno-nutrition data
结局指标
主要结局
Pathological response
时间窗: One month after surgery
Pathological response
次要结局
- 3-years disease-free survival(Three years after surgery)
- yp TNM Stage(One month after surgery)
- Postoperative morbidity(One month after surgery)
- 3-years overall survival(Three years after surgery)
研究者
Shuang-xi Li
Associate Chief Surgeon
Peking University