The Analysis of Immuno-Nutrition Index in Advanced Gastric Cancer Receiving Preoperative Treatments: Observational Cohort Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Gastric Cancer
- Sponsor
- Peking University
- Enrollment
- 600
- Locations
- 1
- Primary Endpoint
- Pathological response
- Status
- Recruiting
- Last Updated
- 8 years ago
Overview
Brief Summary
Based on multiple studies, the immune (systemic inflammation) and nutrition index were correlated with short- and long-term prognosis for gastric cancer. With the increasing application of preoperative treatments (chemotherapy and chemoradiotherapy), the issues concerning how are the immuno-nutrition index be altered under the effects of perioperative treatments and what are the clinical values of these index should be clarified.
Detailed Description
The immune (systemic inflammation) index includes: NLR (Neutrophil-to-Lymphocyte Ratio); PLR (Platelet-to-Lymphocyte Ratio); SII (Systemic Immune-Inflammation Index); GPS (Glasgow Prognostic Score); mGPS (modified Glasgow Prognostic Score); PI (Prognostic Index); The nutrition index includes: NRS2002; PNI (Prognostic Nutrition Index);
Investigators
Shuang-xi Li
Associate Chief Surgeon
Peking University
Eligibility Criteria
Inclusion Criteria
- •Histologically confirmed adenocarcinoma
- •Received neoadjuvant (preoperative) chemotherapy or chemoradiotherapy
- •Diagnosed clinical advanced gastric cancer or esophagogastric cancer
Exclusion Criteria
- •Lack of immuno-nutrition data
Outcomes
Primary Outcomes
Pathological response
Time Frame: One month after surgery
Pathological response
Secondary Outcomes
- 3-years disease-free survival(Three years after surgery)
- yp TNM Stage(One month after surgery)
- Postoperative morbidity(One month after surgery)
- 3-years overall survival(Three years after surgery)