Pain-related Evoked Potentials in Unilateral Peripheral Nerve Injuries

Completed

• Conditions: Peripheral Nerve Injuries
• Interventions: Diagnostic Test: Pain-related evoked potentials (PREP); Diagnostic Test: Quantitative Sensory Testing (QST); Diagnostic Test: Nerve conduction studies (NCS)

• Registration Number: NCT03082820
• Lead Sponsor: Ruhr University of Bochum

Brief Summary

The study examines pain-related evoked potentials (PREP) in patients with peripheral nerve injuries. Since previous studies found altered latencies and amplitudes of PREP in generalized polyneuropathies, e. g. HIV-polyneuropathy and fibromyalgia, this study investigates if these alterations are detectable in unilateral peripheral nerve injuries as well.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-02-03
• Primary Completion: 2016-11-05
• Study Completion: 2016-11-05
• Status Verified: 2017-03
• Study First Submitted: 2017-03-06
• Study First Submitted QC: 2017-03-12
• Study First Posted: 2017-03-17
• Last Update Submitted: 2017-03-17
• Last Update Posted: 2017-03-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• Peripheral Nerve Injury

Exclusion Criteria

• Polyneuropathy
• Contralateral peripheral nerve injury
• Severe psychiatric disorders
• Disorders affecting central nervous system

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Controls	Pain-related evoked potentials (PREP)	Pain-related evoked potentials (PREP) and Quantitative Sensory Testing (QST) were performed with healthy adults.
Controls	Quantitative Sensory Testing (QST)	Pain-related evoked potentials (PREP) and Quantitative Sensory Testing (QST) were performed with healthy adults.
Patients	Pain-related evoked potentials (PREP)	Pain-related evoked potentials (PREP), Quantitative Sensory Testing (QST) and nerve conduction studies (NCS) were performed with patients with peripheral nerve injury.
Patients	Quantitative Sensory Testing (QST)	Pain-related evoked potentials (PREP), Quantitative Sensory Testing (QST) and nerve conduction studies (NCS) were performed with patients with peripheral nerve injury.
Patients	Nerve conduction studies (NCS)	Pain-related evoked potentials (PREP), Quantitative Sensory Testing (QST) and nerve conduction studies (NCS) were performed with patients with peripheral nerve injury.

Primary Outcome Measures

Name	Time	Method
N1-latency	1 day	N1-latency of pain-related evoked potentials in ms

Secondary Outcome Measures

Name	Time	Method
N1P1-amplitude	1 day	Amplitude of pain-related evoked potentials in µV