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Clinical Trials/NCT04050774
NCT04050774
Completed
Not Applicable

Balance Control Mechanisms During Perturbed Standing Across the Lifespan

Hasselt University1 site in 1 country41 target enrollmentNovember 21, 2018
ConditionsChildren, Adult

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Children, Adult
Sponsor
Hasselt University
Enrollment
41
Locations
1
Primary Endpoint
Contribution of the counter-rotation mechanism to centre of mass acceleration based on 3D movement registration and ground reaction forces
Status
Completed
Last Updated
3 years ago

Overview

Brief Summary

Falls are the leading cause of nonfatal injuries in children and elderly. To understand the causes of falling in these populations, fundamental knowledge of how ageing affects balance control is of utmost importance.

In general, two biomechanical mechanisms allow people to control balance; 1.moving the center of pressure within the base of support using ankle muscle activation; 2.counter-rotating segments around the center of mass. To understand how balance is controlled differently across the lifespan, 4 age groups (each N=20) will be compared to each other; i.e. prepubertal children (6-9y), postpubertal children (15-17y), young adults (18-24y), healthy non-falling older adults (65-80y). .

A force plate platform combined with 3D movement registration will be used to determine the biomechanical balance control strategy across the lifespan during unperturbed and perturbed standing. The innovative but focused scope of this study could provide a breakthrough in our biomechanical understanding of balance control and, in particular, the changes in limitations of balance control in childhood and an ageing (fall-prone) population. The gained fundamental knowledge could lead to unprecedented insights in the causes of falling across the lifespan and in possible targets for intervention.

Registry
clinicaltrials.gov
Start Date
November 21, 2018
End Date
April 1, 2021
Last Updated
3 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Hasselt University
Responsible Party
Principal Investigator
Principal Investigator

Pieter Meyns

Principal Investigator

Hasselt University

Eligibility Criteria

Inclusion Criteria

  • prepubertal children (6-9y)
  • postpubertal children (15-18y)
  • young adults (18-24y)
  • healthy non-falling older adults (65-80y) will be included if they 1) did not experience two or more falls during normal daily activities in the preceding year and 2) have no cognitive impairment (tested with Mini-Mental state examination).

Exclusion Criteria

  • inability to speak and understand Dutch;
  • inability to maintain independent unsupported stance for 60 seconds;
  • current diagnosis of neurological or sensory disorders;
  • recurrent dizziness;
  • a history of orthopaedic disorders;
  • surgical operation of the lower extremity during last two years;
  • use of drugs affecting the CNS or known to affect balance control.

Outcomes

Primary Outcomes

Contribution of the counter-rotation mechanism to centre of mass acceleration based on 3D movement registration and ground reaction forces

Time Frame: day 1

The contribution of the counter-rotation mechanism (change in angular momentum (in kg.m2/s2)) to centre of mass acceleration in the sagittal and frontal plane will be calculated based on total body kinematics (SIMI motion - 3D movement registration) and kinetics (AMTI force plate) (calculations based on; van Dieen JH, van Leeuwen M, Faber GS. Learning to balance on one leg: motor strategy and sensory weighting. J Neurophysiol. 2015;114(5):2967-82.))

Contribution of the ankle strategy to centre of mass acceleration based on 3D movement registration and ground reaction forces

Time Frame: day 1

The contribution of the ankle strategy (difference between the centre of pressure and the centre of mass (in kg.m2/s2)) to centre of mass acceleration in the sagittal and frontal plane will be calculated based on total body kinematics (SIMI motion - 3D movement registration) and kinetics (AMTI force plate) (calculations based on; van Dieen JH, van Leeuwen M, Faber GS. Learning to balance on one leg: motor strategy and sensory weighting. J Neurophysiol. 2015;114(5):2967-82.)

Balance Control; centre of mass acceleration based on 3D movement registration and ground reaction forces

Time Frame: day 1

Centre of mass acceleration (in kg.m2/s2) (calculations based on; van Dieen JH, van Leeuwen M, Faber GS. Learning to balance on one leg: motor strategy and sensory weighting. J Neurophysiol. 2015;114(5):2967-82.)

Study Sites (1)

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