PERSISTENT PAIN FOLLOWING THORACIC SURGERY
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- To identify incidence and severity and nature of persistent pain at 3 and 6 months following thoracic surgery with intercostal incisions.
研究概览
简要总结
One of the most severe typesof postoperative pain is following a thoracotomy. Presence of inadequateanalgesia usually results in inability to breathe deeply and cough forcefully,both of which hamper postoperative pulmonary rehabilitation with subsequentretention of secretions, atelectasis and pneumonia1. Analgesictechniques such as Intercostal, paravertebral, interpleural and thoracicepidurals with local anesthetic and opioids have been employed for pain relief.2 Thoracic epidural analgesia (TEA) is by far the bestoption of relieving pain following a thoracotomy, especially with lowconcentration of local anesthetic and a lipophilic opioid.3Neuropathic pain following thoracotomy, known as post thoracotomy pain iscommon , sometimes severe enough to incapacitate and often becomes chronic.4,5Post-thoracotomypain syndrome or PTPS (chronic post-thoracotomy pain or post-thoracotomyneuralgia) is defined by the International Association for the Study of Pain(IASP) as ‘pain that recurs or persists along a thoracotomy incision at leasttwo months following the surgical procedure’. In general, it is burning andstabbing pain with dysesthesia and thus shares many features of neuropathicpain6. Over the years there has been agradual shift towards minimally invasive or thoracoscopic or VATS (videoassisted thoracoscopic surgery) approach. This approach has shown early andbetter recovery with early discharge from the hospital.7 Despitebeing less invasive, VATS procedures have not had a favourable impact on painas was anticipated.8 They too present with similar pain andsometimes even after discharge, and have been reported to be of neuropathicnature.9,10 The incidence of Chronic Post surgical pain11,12following VATS approach has been reported in the range of 20-47%.
Grosen et al13,reported sensory changes in the painful area in 62% patients with postthoracotomy pain syndrome. Simultaneous occurrence of pain and sensorydisturbances caused by nerve injury is one of the mechanisms believed to causePTPS.14 However, it has been noticed that, sensory disturbances arenot always associated with pain15.
At Tata Memorial Hospital, over the last 10 years there hasbeen as steady shift towards minimally invasive VATS approach for thoracicsurgeries. A thoracic epidural catheterization, which is an important aspectfor providing analgesia for thoracotomy, is seldom employed in those undergoingVATS approach. The trend is to use IV opioids intraoperatively along withNSAIDS (if not contraindicated) & Paracetamol along with IV PCA (Patientcontrolled analgesia) postoperatively.
The purpose of the study is to determine the incidence,nature and severity of persistent pain if any at 3 and 6 months following thoracicsurgery with intercostal incisions
REFERENCES
1. PerttunenK, Nilsson E, Heinonen J, Hirvisalo EL, Salo JA, Kalso E. Extradural,paravertebral and intercostal nerve blocks for post-thoracotomy pain. Britishjournal of anaesthesia. 1995 Nov 1;75(5):541-7.
2. GottschalkA, Cohen SP, Yang S, Ochroch EA, Warltier DC. Preventing and treating painafter thoracic surgery. The Journal of the American Society ofAnesthesiologists. 2006 Mar 1;104(3):594-600
3. SlingerP, editor. Principles and practice of anesthesia for thoracic surgery. SpringerScience & Business Media; 2011 Jul 12
4. KarmakarMK, Ho AM. Postthoracotomy pain syndrome. Thorac Surg Clin. 2004Aug;14(3):345-52. doi: 10.1016/S1547-4127(04)00022-2. PMID: 15382766 5.ButlerS,Jonzon B, Branting-Ekenback C et al.Predictors of severe pain in a cohort of5271 individuals with self reported neuropathic pain. Pain 2013;154:141-6.
6. Koehler RP, Keenan RJ. Management of postthoracotomypain: acute and chronic.
ThoracSurg Clin. 2006 Aug;16(3):287-97. doi: 10.1016/j.thorsurg.2006.05.006. PMID:17004557
7. DokiY, Ichiki K, Tsuda M et al. Complete port-accessed lobectomy by the musclesparing method.Ann Thoracic Surg;77:2230-1
8. LandreneauRJ, Mack MJ, Hazelrigg SR, Naunheim K, Dowling RD, Ritter P, Magee MJ, NunchuckS, Keenan RJ, Ferson PF. Prevalence of chronic pain after pulmonary resectionby thoracotomy or video-assisted thoracic surgery. The Journal of thoracic andcardiovascular surgery. 1994 Apr 1;107(4):1079-86
9. HommaT, Doki Y, Yamamoto Y, Ojima T, Shimada Y, Kitamura N, Yoshimura N. Riskfactors of neuropathic pain after thoracic surgery. Journal of ThoracicDisease. 2018 May;10(5):2898
10. BaymanEO, Parekh KR, Keech J, Selte A, Brennan TJ. A prospective study of chronicpain after thoracic surgery. Anesthesiology. 2017 May;126(5):938-51.
11. Wang H, Li S, Liang N , Liu W, Liu H. Postoperative painexperiences in Chinese adult patientsafter thoracotomy and VATS surgery.J Clin Nurs. 2017;20(17-18) : 2744-2754
12. Weinrib AZ, Azam MA, Birnie KA, Burns LC, Clarke H, KatzJ. The psychology of chronic post-surgical pain : new frontiers in risk factoridentification, prevention and management. Br. J. Pain. 2017;11(4):169-177
13. GrosenK, Laue PG, Pfeiffer-Jensen M, Hoejsgaard A, Pilegaard HK. Persistentpostsurgical pain following anterior thoracotomy for lung cancer: across-sectional study of prevalence, characteristics and interference withfunctioning. Eur J Cardiothorac Surg.
2013;43(1):95–103
14. Doan LV, Augustus J, Androphy R, Schechter D, Gharibo C.Mitigating the impact of acute and chronic post-thoracotomy pain. J CardiothoracVasc Anesth. 2014 Aug;28(4):1048-56. doi: 10.1053/j.jvca.2014.02.021. PMID:25107721.
15. Wildgaard K, Ravn J, Nikolajsen L, Jakobsen E, Jensen TS,Kehlet H. Consequences of persistent pain after lung cancer surgery: anationwide questionnaire study. Acta Anaesthesiol Scand. 2011 Jan;55(1):60-8.doi: 10.1111/j.1399-6576.2010.02357.x. Epub 2010 Nov 15. PMID: 21077845.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)(—)
- 性别
- All
入选标准
- •adults undergoing thoracic surgery with intercostal incisions, all lateral incisions including single port/Multiple port.
- •can read and write in English/Hindi/Marathi.
排除标准
- •<18 years of age -History of prior thoracic surgery -Preoperative neuropathic pain -A median sternotomy incision -Unwilling to fill out a questionnaire -Refusal of consent -Cognitively impaired -Emergency surgery.
结局指标
主要结局
To identify incidence and severity and nature of persistent pain at 3 and 6 months following thoracic surgery with intercostal incisions.
时间窗: 180 days
次要结局
- -Postoperative pain severity and association with persistent pain(-Postoperative Analgesia techniques and association with persistent pain)
