Mechanisms of Stroke in Intracranial Stenosis

Terminated

• Conditions: Stroke

• Registration Number: NCT01152944
• Lead Sponsor: Jose Romano, MD

Brief Summary

The objective of this SAMMPRIS-affiliated study is to understand the mechanisms the mechanisms that underlie ischemic stroke recurrence in high-grade intracranial atherosclerotic disease in order to determine predictors of recurrent stroke. MoSIS will evaluate 6 specific mechanisms of stroke in the medically-treated SAMMPRIS cohort: decreased antegrade flow, progression of stenosis, decreased proximal collateral flow, decreased distal collateral flow, impaired cerebrovascular reserve, and artery-to-artery embolism.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-06-28
• Study First Submitted QC: 2010-06-28
• Study First Posted: 2010-06-29
• Study Start: 2010-07
• Primary Completion: 2011-04
• Study Completion: 2011-12
• Status Verified: 2012-02
• Last Update Submitted: 2012-02-06
• Last Update Posted: 2012-02-07

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Enrolled in the medical arm of SAMMPRIS, signed consent

Exclusion Criteria

• For QMRA testing: contraindications to MRI; for TCD testing, abscence of ultrasonographic windows.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ischemic stroke in the territory of the stenotic artery	2 years from enrollment

Trial Locations

Locations (1)

University of Miami; 🇺🇸 Miami, Florida, United States