Small Intestinal Adaptation to Isocaloric Diets Dominated Either by Fats or Carbohydrates
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Mucosal Surface Enlargement
研究概览
简要总结
Human beings are 'omnivores' meaning that all principal components of food (i.e. the macronutrients: carbohydrates, fat, proteins) can be assimilated by the gastrointestinal tract. When the gut mucosa is exposed to dietary changes it adjusts its functional behaviour. For example, a fatty diet demands certain digestive mechanisms, whereas others are needed to take care of a carbohydrate rich diet. Such dietary induced changes in appearance and functionality of the small intestinal mucosa have been described in animals but only little is known about it in man. The present project aims at elucidating in man if a 2 weeks diet dominated by either fat or carbohydrates, but with similar energy content, is associated with changes in the small intestinal mucosal appearance and metabolic signalling capacity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteer not taking prescribed medications BMI ≤25 kg/m2
排除标准
- •BMI ≥26 kg/m2 smoker previous or current gastrointestinal disease significant abdominal surgery pregnancy/breast feeding drug intolerance of importance (particularly opiates and midazolam used during endoscopy) history of drug addiction
研究组 & 干预措施
First high fat diet, then high carbohydrate diet
had; first sixty percent fat as the energy source, then sixty percent carbohydrates
干预措施: high fat diet (hfd), then high carbohydrate diet (Dietary Supplement)
First, high carb diet, then high fat diet
had; first sixty percent carbohydrates as the energy source, the sixty percent fat
干预措施: high carbohydrate diet, then high fat diet (Dietary Supplement)
结局指标
主要结局
Mucosal Surface Enlargement
时间窗: Appearance after 2 weeks of each diet
The enlargement of the luminal surface area is a morphometric factor, defined as the percentage of the mucosal surface (one dimension in arbitrary units) in relation to the relatively flat area of the muscular mucosae layer from the same histological cuts. Unit: % of the muscular mucosae.
Mucosal Surface Enlargement
时间窗: Appearance after 2 weeks of each diet
The enlargement of the luminal surface area is a morphometric factor, defined as the percentage of the mucosal surface (one dimension in arbitrary units) in relation to the relatively flat area of the muscular mucosae layer from the same histological cuts. Unit: % of the muscular mucosae.
次要结局
- Glycemic Control Following a Test Meal(The condition after 2 weeks of each diet)
- Glucose Induced Electrogenic Responses In-vitro(The condition after 2 weeks of each diet)
- Glycemic Control Following a Test Meal(The condition after 2 weeks of each diet)