Evaluation of the Brain Natriuretic Peptide as a Predictor of Morbidity and Mortality in Cardiac Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- University Hospital, Strasbourg, France
- Enrollment
- 500
- Locations
- 1
- Primary Endpoint
- BNP levels; hospital and long-term morbidity and mortality
- Last Updated
- 10 years ago
Overview
Brief Summary
Objective: The purpose of the present study is to assess if perioperative variation of Brain Natriuretic Peptide (BNP) levels is a predictor of mortality and morbidity after cardiac surgery.Material and Methods: 500 consecutive patients will be enrolled prospectively in this study before cardiac surgery under cardiopulmonary bypass. BNP levels will be measured prior to surgery and at postoperative day 1. Variations of BNP levels will be analyzed to determine if it is a predictor of mortality and morbidity after cardiac surgery. This dynamic evaluation will be compared to other tools of risk stratification in cardiac surgery as the EuroScore. All patients will be followed 3 years after the procedure.
Hypothesis: Perioperative BNP variations may be more sensitive than pre- or postoperative BNP levels alone. Furthermore the perioperative homeostasis will be measured to assess its impact on BNP secretion during the perioperative period.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patient who need cardiac surgery
- •Age \> 18 years
Exclusion Criteria
- •Patient on mechanic ventilation before surgery
- •Aortic dissection-Congenital disease
Outcomes
Primary Outcomes
BNP levels; hospital and long-term morbidity and mortality
Time Frame: BNP levels prior to surgery and at postoperative day 1; Hospital and long-term morbidity and mortality (1, 2 and 3 years)
Secondary Outcomes
- EuroScoreCardiac markers; inflammation markers; echocardiography(EuroScoreCardiac markers at day 1, 2, 5; Inflammation markers at day 1, 2, 5; Echocardiography (day 5, and 1, 2 and 3 years))