"Effect of Tadalafil, Sildenafil and Pentoxyfylline on Endometrial Thickness and Frozen Embryo Transfer Outcomes
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- endometrial thickness
研究概览
简要总结
The aim of this study is to investigate the Effect of different vasodilators as Tadalafil, Sildenafil and pentoxyfylline in In vitro Fertilization. In addition, the thickness of endometrium and pregnancies rates of these women will also be examined. All adverse effects of all drugs will be estimated
详细描述
A prospective randomized clinical study will be conducted in the IVF clinic of the gynecology department of Beni Suef University Hospital, Beni-Suef, Egypt. The study will These patients will be randomized into four groups.
The participants will take drugs starting from the end of menstruation cycle till endometrium reach optimal and then will start progesterone 800 mg daily.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •women having thawed embryos
排除标准
- •hypotension
- •cardiovascular, hepatic, and renal diseases;
- •uncontrolled diabetes mellitus;
- •ovarian cysts;
- •hyperprolactinemia;
- •abnormal thyroid functions;
- •uterine fibroids;
- •patients taking nitrates;
- •endometriosis and adenomyosis
研究组 & 干预措施
tadalafil
tadalafil 10 mg one tablet daily
干预措施: tadalafil (Drug)
pentoxifylline
pentoxyfilline 400 mg two tabs daily
干预措施: pentoxifylline (Drug)
sildenafil
sildenafil 20 mg two tablets
干预措施: Sildenafil (Drug)
结局指标
主要结局
endometrial thickness
时间窗: within 16 day of menstruation
measured by transvaginal ultrasound
次要结局
- pregnancy rate(1 month)
研究者
Sara Abdallah Mohamed Salem
Lecturer of Gynecology and obstetrics Faculty of medicine Beni-Suef University
Beni-Suef University