Effect of Tadalafil, Sildenafil and Pentoxyfylline on Frozen Embryo Transfer Outcomes
- Conditions
- IVF
- Interventions
- Registration Number
- NCT05971667
- Lead Sponsor
- Beni-Suef University
- Brief Summary
The aim of this study is to investigate the Effect of different vasodilators as Tadalafil, Sildenafil and pentoxyfylline in In vitro Fertilization. In addition, the thickness of endometrium and pregnancies rates of these women will also be examined. All adverse effects of all drugs will be estimated
- Detailed Description
A prospective randomized clinical study will be conducted in the IVF clinic of the gynecology department of Beni Suef University Hospital, Beni-Suef, Egypt. The study will These patients will be randomized into four groups.
The participants will take drugs starting from the end of menstruation cycle till endometrium reach optimal and then will start progesterone 800 mg daily.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- Female
- Target Recruitment
- 200
- women having thawed embryos
- hypotension
- cardiovascular, hepatic, and renal diseases;
- uncontrolled diabetes mellitus;
- ovarian cysts;
- hyperprolactinemia;
- abnormal thyroid functions;
- uterine fibroids;
- patients taking nitrates;
- endometriosis and adenomyosis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description pentoxifylline pentoxifylline pentoxyfilline 400 mg two tabs daily tadalafil tadalafil tadalafil 10 mg one tablet daily sildenafil Sildenafil sildenafil 20 mg two tablets
- Primary Outcome Measures
Name Time Method endometrial thickness within 16 day of menstruation measured by transvaginal ultrasound
- Secondary Outcome Measures
Name Time Method pregnancy rate 1 month number of cases positive serum pregnancy test
Trial Locations
- Locations (1)
Beni-suef university Hospital
馃嚜馃嚞Ban墨 Suwayf, Beni Suef, Egypt