Application of Different Modes of Esketamine Administration in Pediatric Day Circumcision
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 主要终点
- One-time success rate of anesthesia
研究概览
简要总结
To explore the application of different administration modes of esketamine in pediatric day circumcision, in order to find an anesthesia scheme more suitable for day pediatric circumcision.
详细描述
The current clinical study believes that esketamine is suitable for pediatric anesthesia because of its advantages of light respiratory depression, low secretions, low incidence of psychomotor reactions and fast recovery of anesthesia, but there are few related studies on its administration mode and timing in clinical application, this study aims to explore the application of different administration methods of esketamine in pediatric day circumcision, and find an anesthesia scheme more suitable for day circumcision, in order to provide new ideas for anesthesia for pediatric day circumcision.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 6 Years 至 12 Years（Child）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists (ASA) class I and II children
- •Age 5-12 years
- •Foreskin cerclage is proposed
- •No history of upper respiratory tract infection in the past two weeks
- •Obtain the consent of the child's family
排除标准
- •Hepatic and renal insufficiency, coagulation dysfunction
- •Those who are allergic to esketamine
- •History of cognitive impairment
- •other psychiatric and neurological disorders
研究组 & 干预措施
single group
give esketamine 0.75 mg/kg at the time of induction
干预措施: Esketamine of single injection (Drug)
intermittent group
give esketamine 0.5mg/kg during anesthesia induction, and during the measuring ring esketamine 0.25mg/kg was given again
干预措施: Esketamine of Intermittent injection (Drug)
结局指标
主要结局
One-time success rate of anesthesia
时间窗: During surgery
No movement during anesthesia
次要结局
- Time to talk(During surgery)
- intraoperative propofol dosage, esketamine dosage(During surgery)
- Time to open eyes(During surgery)
- Duration of surgery(During surgery)
- Systolic blood pressure(During surgery)
- Diastolic blood pressure(During surgery)
- Heart rate(During surgery)
- VAS(visual analogue scale) score(12 hours after the end of surgery)
- Incidence of adverse effects (hypotension, hypertension, respiratory depression, postoperative pain, diplopia, mania)(12 hours after the end of surgery)
研究者
Wang wanxia
Principal Investigator
Yangzhou University