Efficacy of combination therapy of angiotensin II receptor blocker (ARB) and diuretic in hypertensive patients with chronic kidney disease (CKD)
- Conditions
- Hypertension
- Registration Number
- JPRN-UMIN000003919
- Lead Sponsor
- Kyoto University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 30
Not provided
1) Patients with uncontrolled hypertension (DBP >= 110mmHg) 2) Patients with malignant hypertension 3) Patients with uncontrolled diabetes (HbA1c >= 8.0%) and patients under insulin treatment 4) Patients who have stroke, AMI and/or critical vascular complications that required hospitalization within 6 months prior to the intervention 5) Patients with liver dysfunction [GPT(ALT) over three times the normal value] 6) Patients with critical renal failure (serum creatinine >= 3.0 mg/dL) 7) Patients with a previous history of gout attack or uncontrolled hyperuricemia (UA >= 9.0mg/dL) 8) Pregnant or breast feeding female patients, including one trying to conceive pregnancy during the planned study period 9) Patients with uncontrolled arrhythmia 10) Patients with cardiac insufficiency (NYHA grade III or IV) 11) Patients with a history of hypersensitivity to ingredients of losartan 12) Patients with a history of hypersensitivity to thiazide or thiazide-like diuretics 13) Patients who are considered not eligible for the study by the attending doctor due to medical reasons
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change and % change in blood pressure after 3 months of treatment
- Secondary Outcome Measures
Name Time Method - Change and % change in blood pressure after 1 and 6 months of treatment - Change and % change in eGFR, urinary albumin excretion, serum uric acid, BNP, urinary 8OHdG and urinary Ngal after 3 and 6 months of treatment