Comparative study of the renal toxicity of dosage regimen containing high and conventional doses of colistin with monitoring of novel biomarkers of acute kidney injury

Not Applicable

• Conditions: Condition 1: patients with hospital acquired infections due to multi drug resistant gram negative organisms. Condition 2: patients with hospital acquired infections due to multi drug resistant gram negative organisms. Condition 3: patients with hospital acquired infections due to multi drug resistant gram negative organisms.; Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters; Other specified sepsis; Other and unspecified infectious diseases

• Registration Number: IRCT2014090614693N5
• Lead Sponsor: Faculty of Pharmacy, Shahid Beheshti university of medical sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Inclusion: candidate for colistin therapy; at least 7 days colistin therapy; age 18-65
Exclusion: chronic kidney injury (GFR<60); Acute kidney injury; BMI>35; patient discontent

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum cystatin c level. Timepoint: day 1(before first dose), 3, 5, 7, 10. Method of measurement: biochemisty kit.

Secondary Outcome Measures

Name	Time	Method
Change in serum creatinin level and GFR. Timepoint: first 10 days of treatment. Method of measurement: GFR with cockroft gault equation.;Added at 2016-08-10: Neutrophil gelatinase-associated lipocalin (NGAL). Timepoint: Added at 2016-08-10: day 1, 3, 5, 7, 10. Method of measurement: Added at 2016-08-10: ELISA kit.