Research of pharmacokinetic and pharmacogenetic determinants of the activity and toxicity of 5-Fluorouracil in colorectal cancer patients
Not Applicable
- Conditions
- Colorectal cancer
- Registration Number
- JPRN-UMIN000004095
- Lead Sponsor
- Department of clinical pharmacokinetics, Graduate school of Pharmaceutical Science, Kyushu University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Not provided
Exclusion Criteria
1) Hoped to be pregnant/nursing. 2) Allergy to fluoropyrimidine compounds 3) Simultaneous use of other fluoropyrimidine drugs 4) History of severe complicating disease 5) Active infection 6) History of bone-marrow transplantation 7) Those who received a white blood cell transfusion within 30 days before registration 8) Those judged to be not suitable by the attending physician
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the relationship between 5-FU pharmacokinetics and plasma biomarkers.
- Secondary Outcome Measures
Name Time Method