Potentially Inappropriate Prescription Associated to Multimorbidity, Using the Explicit STOPP-START (Screening Tool of Older Persons' Potentially Inappropriate Prescriptions/Screening Tool to Alert Doctors to the Right Treatment) Criteria
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 740
- 试验地点
- 1
- 主要终点
- Percentage of patients with Potentially inappropriate medication, according to STOPP-START explicit criteria
研究概览
简要总结
A prospective multicenter cohort study in 5 hospitals in Spain will be initiated in 2016.
Objectives:
- To estimate and describe patterns of multimorbidity and polypharmacy in patients over 64 admitted for a chronic disease exacerbation.
- To analyze the potentially inappropriate prescribing (PPI) drugs according to STOPP / START (SS) criteria.
- To evaluate the relationship between multimorbidity and PPI and adverse medication (RAM) preventable reaction.
The cohort will include 800 patients >64 years admitted in internal medicine and / or geriatric department of 5 hospitals of the National Health Service. Application of the SS criteria (released in 2015) on admission and at discharge, and collection of demographic and clinical variables including comorbidities, baseline chronic medication, geriatric syndromes, functional capacity and RAM. Descriptive analysis and bivariate parametric or nonparametric tests will be applied to analyze relationship between morbidity, polypharmacy, SS criteria and RAM. Intraobserver agreement will be assessed for SS criteria. Multiple regression techniques will be applied, where the dependent variable will be the PPI or the RAM.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient admitted to the Internal Medicine or Geriatrics department
- •Admitted to hospital because of an exacerbation of any previous chronic condition
排除标准
- •Terminal ill patients at admission
- •Patients with lower forecast life than 1 year
- •Patient admitted to the hospital only because an acute problem
- •In patient home care
结局指标
主要结局
Percentage of patients with Potentially inappropriate medication, according to STOPP-START explicit criteria
时间窗: At study entry
次要结局
- Percentage of patients with Potentially inappropriate medication, according to STOPP-START explicit criteria(Through study completion, an average of 2 years)
- Percentage of patients with polypharmacy(At study entry)
- Patients with any treatment-related adverse events (ADR), according to the Wills & Brown classification(Through study completion, an average of 2 years)
- Percentage of different Patterns of multimorbidity in chronic patients, according to clusters or associations of different chronic conditions(At study entry)
研究者
Marisa Baré, MD, MPH, PhD
Cancer Screening-Epidemiology Coordinator
Corporacion Parc Tauli