The Role of Short Course of Palliative Radiation in Metastatic Cancer Rectum
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 49
- 主要终点
- The role of short course of palliative radiation in metastatic cancer rectum.
研究概览
简要总结
Short-course radiotherapy (SCRT), which allows the delivery of 25 Gy in five daily fractions, has emerged as an attractive strategy for rectal cancer treatment. Surgery can safely be deferred after SCRT, allowing an opportunity to deliver chemotherapy (ChT) preoperatively rather than postoperatively. In cases of metastatic disease, this represents an effective treatment option to improve local control and avoid colostomy in a subset of patients.
详细描述
All patients will be under go complete history and physical examination, proctoscopy and biopsy, followed by metastatic work up include chest X ray, pelvic abdominal CT.
Radiotherapy:
Target volume: all the gross primary disease and gross nodal involved plus 2 cm safety margin will be included. not involved node will not be included.
Dosage: total dose of 25 Gy over 5 fractions through 1 weak will be given. Time: Radiotherapy will be given first and chemotherapy will be given after 1 weak rest to avoid the over lapping toxicity.
Chemo therapy:
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adenocarcinoma pathological evidence in rectal carcinoma.
- •Metastatic unresectable rectal cancer.
- •Symptomatic disease for at least one of the following signs: bleeding, pain, tenesmus, obstruction,
排除标准
- •Previous radiotherapy.
- •Concomitant chemotherapy.
- •Previously created stoma.
结局指标
主要结局
The role of short course of palliative radiation in metastatic cancer rectum.
时间窗: one year
The role of short course of palliative radiation in metastatic cancer rectum.
次要结局
未报告次要终点
研究者
Ehdaa Khaled Mahmoud
resident doctor at radiotherapy department at south Egypt cancer institute
Assiut University