COMPARISION OF ADDITION OF FENTANYL V/S NEOSTIGMINE TO BUPIVACAINE IN UPPER LIMB SURGERIES FOR DURATION OF ANALGESIA

Recruiting

• Registration Number: CTRI/2021/01/030277
• Lead Sponsor: NOT APPLICABLE

Brief Summary

This study is  designed to  

1. To find out the comparative efficacy of bupivacaine with fentanyl vs bupivacaine with neostigmine for onset, duration of sensory and motor block with duration of analgesia.

2. To observe side effects of drugs among the different groups.



Fentanyl  has been used for regional nerve plexus blocks to improve the block duration and quality. The peripheral administration of opioids provides effective and long lasting analgesia without central side effects.Studies have shown better block duration and success rate of brachial plexus block on addition of fentanyl. Whereas neostigmine decreases the breakdown of acetylcholine by its inhibitory action on acetylcholinesterase, preclinical data suggests peripheral anti-nociceptive effects of acetylcholine due to its accumulation, resulting prolongation of nerve block with hemodynamic stability.



We hypothesized that peripheral nerve block with isobaric 0.25% bupivacaine and Fentanyl would be comparable to isobaric 0.25% bupivacaine and Neostigmine for the efficacy of anesthesia and analgesia, and in addition would provide a better postoperative recovery profile and readiness for discharge.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-17
• Last Update Posted: 2021-07-30

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

PATIENTS POSTED FOR UPPER LIMB FRACTURE SURGERIES OF PROBALE DURATION OF 2 HOURS ASA I & II.

Exclusion Criteria

PATIENTS REFUSAL ALLERGY TO LOCAL ANAESTHETICS & USED ADJUVENTS LOCAL SITE INFECTION NEURODEGENERATIVE DISORDERS IN UPPER LIMB BLEEDING COAGULOPATHY PATIENT WITH HEPATIC & RENAL DISORDERS.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
DURATION OF ANALGESIA	AFTER 2 HOUR EVERY 10 MIN POSTOPERATIVELY

Secondary Outcome Measures

Name	Time	Method
DURATION OF SENSORY AND MOTOR BLOCK	AFTER 2 HOUR EVERY 10 MIN POSTOPERATIVELY

Trial Locations

Locations (1)

TRAUMA CENTER INSTITUTE OF MEDICAL SCIENCES BHU; 🇮🇳 Varanasi, UTTAR PRADESH, India

TRAUMA CENTER INSTITUTE OF MEDICAL SCIENCES BHU

🇮🇳Varanasi, UTTAR PRADESH, India

DR SANDEEP LOHA

Principal investigator

8960919866

drsandeepscb@gmail.com