Effect of a Triclosan Containing Dentifrice on Oral Bacteria and Postoperative Complications Following Third Molar Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 141
- 试验地点
- 2
- 主要终点
- dry socket
研究概览
简要总结
Triclosan containing dentifrices are effective in the prevention of inflammatory complications following third molar surgery through reducing preoperative oral bacteria load.
详细描述
This study may provide evidence on the effect of triclosan containing dentifrice on oral bacteria and oral inflammation prior to third molar surgery, and on the incidence of inflammatory complications after the surgery. If proven effective, dentifrice containing triclosan may be recommended prior to tooth extractions and replace antibiotics and other antimicrobial products as a prophylactic procedure before oral surgery procedures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •must include at least one mandibular third molar with partial or full bony impaction
- •no sign of active pericoronal (around the crown) infections
- •must have not taken antibiotics for any reason in the past 30 days
- •must be healthy and between 18 and 35 years of age
- •must be able to read and sign an informed consent
排除标准
- •Subjects with systemic diseases and pregnant or lactating women
- •Subjects with advanced periodontal diseases or having two or more untreated caries lesions
- •Subjects who cannot read and sign an informed consent
- •Subjects with signs of pericoronal infections
结局指标
主要结局
dry socket
时间窗: 3 to 7 days
Development of dry socket (alveolar osteitis) 3 to 7 days after tooth extraction
次要结局
- wound infection(3 to 7 days)
研究者
Yanfang Ren
Professor
University of Rochester