Triclosan Toothpaste and Third Molar Surgery

Not Applicable

Completed

• Conditions: Dry Socket; Wound Infection

• Registration Number: NCT01292343
• Lead Sponsor: University of Rochester

Brief Summary

Triclosan containing dentifrices are effective in the prevention of inflammatory complications following third molar surgery through reducing preoperative oral bacteria load.

Detailed Description

This study may provide evidence on the effect of triclosan containing dentifrice on oral bacteria and oral inflammation prior to third molar surgery, and on the incidence of inflammatory complications after the surgery. If proven effective, dentifrice containing triclosan may be recommended prior to tooth extractions and replace antibiotics and other antimicrobial products as a prophylactic procedure before oral surgery procedures.

Study Timeline

• Study Start: 2008-02
• Study First Submitted: 2011-02-04
• Study First Submitted QC: 2011-02-07
• Study First Posted: 2011-02-09
• Primary Completion: 2013-02
• Study Completion: 2013-02
• Status Verified: 2015-10
• Last Update Submitted: 2015-10-26
• Last Update Posted: 2015-10-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 141

Inclusion Criteria

• must include at least one mandibular third molar with partial or full bony impaction
• no sign of active pericoronal (around the crown) infections
• must have not taken antibiotics for any reason in the past 30 days
• must be healthy and between 18 and 35 years of age
• must be able to read and sign an informed consent

Exclusion Criteria

• Subjects with systemic diseases and pregnant or lactating women
• Subjects with advanced periodontal diseases or having two or more untreated caries lesions
• Subjects who cannot read and sign an informed consent
• Subjects with signs of pericoronal infections

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
dry socket	3 to 7 days	Development of dry socket (alveolar osteitis) 3 to 7 days after tooth extraction

Secondary Outcome Measures

Name	Time	Method
wound infection	3 to 7 days	Development of tooth extraction wound infection 3 to 7 days after extraction

Trial Locations

Locations (1)

University of Rochester Eastman Dental Center; 🇺🇸 Rochester, New York, United States