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Clinical Trials/NCT05950438
NCT05950438
Recruiting
Not Applicable

A Prospective Clinical Registry Investigating Outcomes of Elective Robotic Transhiatal Esophagectomy

Northwestern University1 site in 1 country25 target enrollmentJuly 11, 2023
ConditionsEsophagectomy

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Esophagectomy
Sponsor
Northwestern University
Enrollment
25
Locations
1
Primary Endpoint
Number of Participants with Esophageal Stricture
Status
Recruiting
Last Updated
last year

Overview

Brief Summary

The primary goal of this study is to collect short-term and long-term health outcomes of a robotic transhiatal esophagectomy procedure. Clinical (or health) outcomes measure the effect of the procedure on your overall health status. During this procedure, the surgeon will remove all or part of your esophagus. We want to identify patients who will have this procedure. We will look at data elements before, during, and after your procedure to understand the impact of this surgery on your post-operative clinical outcomes.

Detailed Description

Esophagectomy is a complex surgical procedure performed to treat various esophageal disorders. The surgery involves the removal of all or part of the esophagus and reconstruction using other parts of the gastrointestinal tract. Different surgical approaches and techniques have been developed, including open (transthoracic or transhiatal), minimally invasive (video-assisted thoracoscopic surgery or robotic-assisted), and hybrid approaches. These techniques may yield different clinical outcomes, and there is still ongoing debate regarding the optimal approach. Nevertheless, minimally invasive approaches, including robotic esophagectomy, are generally preferred given the lower morbidity. This prospective clinical registry aims to investigate outcomes of elective robotic transhiatal esophagectomy, the preferred approach at Northwestern Memorial Hospital, for adult patients undergoing this procedure. By collecting clinical and demographic data prospectively, we hope to identify factors that contribute to improved outcomes and guide future surgical practice.

Registry
clinicaltrials.gov
Start Date
July 11, 2023
End Date
May 25, 2028
Last Updated
last year
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Ankit Bharat

Chief of Thoracic Surgery

Northwestern University

Eligibility Criteria

Inclusion Criteria

  • Adult patients (18 years or older)
  • Patients undergoing elective esophagectomy for any indication
  • Patients who have already had an elective esophagectomy for any indication
  • Patients with consent providing capacity

Exclusion Criteria

  • Patients undergoing emergent esophagectomy
  • Adults unable to consent
  • Individuals who are not yet adults (infants, children, teenagers)
  • Pregnant women
  • Prisoners
  • Vulnerable Populations

Outcomes

Primary Outcomes

Number of Participants with Esophageal Stricture

Time Frame: During first 3 months postop

Postoperative Complication

Number of Participants Requiring Ventilation >48 Hours

Time Frame: During first 3 months postop

Postoperative Complication

Number of Participants with Pulmonary Embolism

Time Frame: During first 3 months postop

Postoperative Complication

Number of Participants with Intensive Care Unit (ICU) Stay

Time Frame: During first 3 months postop

Postoperative Complication

Rates of 30-day Survival

Time Frame: Postoperative

Postoperative Complication

Rates of 90-day Survival Rates

Time Frame: Postoperative

Postoperative Complication

Number of Participants with Anastomotic Leak

Time Frame: During first 3 months postop

Postoperative Complication

Number of Participants with Pneumonia

Time Frame: During first 3 months postop

Postoperative Complication

Number of Participants with Deep Venous Thrombosis

Time Frame: During first 3 months postop

Postoperative Complication

Number of Participants with Stroke

Time Frame: During first 3 months postop

Postoperative Complication

Number of Participants with Myocardial Infarction

Time Frame: During first 3 months postop

Postoperative Complication

Number of Participants with Chylothorax

Time Frame: During first 3 months postop

Postoperative Complication

Number of Participants with Empyema

Time Frame: During first 3 months postop

Postoperative Complication

Number of Participants with Gastric Outlet Obstruction

Time Frame: During first 3 months postop

Postoperative Complication

Number of Participants with Acute Renal Injury

Time Frame: During first 3 months postop

Postoperative Complication

Rates of Re-operation

Time Frame: During first 3 months postop

Postoperative Complication

Rates of Re-Admission

Time Frame: During first 3 months postop

Postoperative Complication

Number of Participants with Atrial Fibrillation

Time Frame: During first 3 months postop

Postoperative Complication

Number of Participants with Vocal Cord Paralysis

Time Frame: During first 3 months postop

Postoperative Complication

Number of Participants with Wound Infections

Time Frame: During first 3 months postop

Postoperative Complication

Rates of Length of Hospital Stay

Time Frame: Postoperative

Postoperative Complication

Secondary Outcomes

  • Operative Time of Surgery(Intraoperative)
  • Number of Participants with Conversion Rates to Open Esophagectomy(Intraoperative)
  • Rates of Blood Loss(Intraoperative)
  • Number of Participants with Lymph nodes in the Final Specimen(Intraoperative)
  • Number of Participants with Proximal and Distal Margins(Intraoperative)

Study Sites (1)

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