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临床试验/NCT07706062
NCT07706062尚未招募不适用

Total Lower Uterine Segmentectomy With Adjunctive Mechanical Towel Compression for the Surgical Management of Placenta Accreta Spectrum Disorders: A Case Series

Assiut University0 个研究点目标入组 30 人开始时间: 2026年9月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
30
主要终点
Estimated intraoperative blood loss

研究概览

简要总结

The goal of this observational study is to evaluate the feasibility and safety of utilizing adjunctive mechanical towel compression during TLS-CCA, measured primarily by estimated intraoperative blood loss in patient with Maternal age 18-45 years - Singleton pregnancy - Antenatal diagnosis of PAS (ultrasound ± MRI) - Planned elective cesarean delivery - Candidate for uterine preservation via TLS-CCA - Provided written informed consent

详细描述

Placenta accreta spectrum (PAS) disorders, characterized by abnormal trophoblastic invasion into the myometrium, have seen a global rise in incidence primarily driven by increasing cesarean delivery rates. Massive obstetric hemorrhage remains the leading cause of maternal morbidity and mortality in these cases.

While cesarean hysterectomy is the traditional gold standard for severe PAS, uteruspreserving procedures are increasingly preferred by patients desiring future fertility. Total lower uterine segmentectomy with cervico-corporeal anastomosis (TLS-CCA) is a recognized conservative technique that involves excising the invaded lower segment and reconstructing the uterus. Despite removing the primary placental implantation site, diffuse bleeding from the highly vascularized remaining myometrial bed, dissected bladder flap, and pelvic collateral vessels often persists. While traditional compression sutures or specialized devices are utilized for hemostasis, they can be costly or technically challenging in distorted anatomies. This study introduces a novel, simple, and cost-effective approach: the use of tightly rolled sterile surgical towelsapplied as direct mechanical compression against the lower uterine segment and bladder bed during dissection and reconstruction.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Prospective

入排标准

年龄范围
18 Years 至 45 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • Maternal age 18-45 years
  • Singleton pregnancy
  • Antenatal diagnosis of PAS (ultrasound ± MRI)
  • Planned elective cesarean delivery
  • Candidate for uterine preservation via TLS-CCA
  • Provided written informed consent

排除标准

  • Hemodynamic instability necessitating emergency hysterectomy
  • Placental invasion into adjacent pelvic organs requiring exenteration
  • Pre-existing severe coagulation disorders
  • Multiple gestation or major fetal anomalies
  • Patient refusal to participate

结局指标

主要结局

Estimated intraoperative blood loss

时间窗: at operation

Estimated intraoperative blood loss by (mL)

次要结局

  • Blood transfusion requirements(intraoperative)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Nourhan Karam Hussein Al Salmany

resident

Assiut University

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