An Investigation Into Risk Taking Behaviour, Bone Microstructure and Fracture Between the Sexes: What Underpins Fracture in Boys Compared to Girls During Growth?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 319
- 试验地点
- 2
- 主要终点
- Characterization of factors that contribute to fractures in boys and girls
研究概览
简要总结
Boys suffer a disproportionately large number of fractures compared to girls (55-60%). This study aims to determine why this is the case by identifying risk factors for wrist fractures. The increase in fracture during childhood and adolescence may be associated with 1) risk-taking behaviour in boys, 2) obesity trends in boys during childhood and adolescence, and/or 3) impaired acquisition of bone strength during childhood and adolescence. Importantly from a knowledge translation perspective, modifiable factors such as behaviour, dietary habits or physical activity in boys may predict fracture.
The investigators will measure 400 children (100 girls and 100 boys who have sustained a fracture; 100 same age and sex friends) across 4 years of growth. This study will assess risk behaviours, diet, physical activity, motor proficiency (i.e., balance and coordination), fat and muscle mass and bone strength to determine if there are, 1) differences in whether all or some of these factors predict fractures in boys compared with girls and, 2) whether these factors track forward similarly in boys compared with girls as children advance through the growth spurt.
详细描述
The investigators aim to better characterize factors that contribute to fracture in boys and girls and to assess whether such factors track across a four year period. The innovation is to use novel methods and an integrated approach, to measure the influence of risk-taking behaviour, body composition, bone microstructure, motor proficiency, diet and physical activity in one model across growth. This will provide a more comprehensive picture of the key multi-factorial predictors of fracture within- and between-sexes. This essential information will provide the basis for change in public health policy, clinical practice, community programs, and targeted interventions.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 8 Years 至 15 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Boys aged 9-15 and Girls aged 8-13
- •Fracture to distal radius after low to moderate energy trauma
- •No other health concerns
- •Healthy (non fracture) subjects for comparison
排除标准
- •Fracture is a result of severe trauma
- •Children with ontological medical conditions
结局指标
主要结局
Characterization of factors that contribute to fractures in boys and girls
时间窗: Baseline (<3 months after injury)
The factors include: 1. Risk taking behaviour - protection motivation variables, anticipated regret and excitement and impulsivity dispositions 2. Body composition - total body mass, fat mass, lean mass 3. Bone microstructure - cortical and trabecular bone outcomes 4. Dietary intake - calcium 5. Physical activity
次要结局
- Tracking of Risk Factors(4 years)
研究者
Heather McKay
Principal Investigator
University of British Columbia