Diagnostic value of copeptin in febrile seizures

• Conditions: cerebral seizures, febrile infection (e. g. with focus in the airways or in the gastrointestinal tract); R56.0; Other and unspecified infectious diseases; Other and unspecified convulsions; B99; Febrile convulsions; R56.8

• Registration Number: DRKS00006251
• Lead Sponsor: Zentrum für Kinder- und Jugendmedizin, Universitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-06-23
• Study Completion: 2018-03-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

1) Children < 6 years presenting at the emergency unit with past or ongoing cerebral seizures.
2) Children < 6 years presenting at the emergency unit without cerebral seizures but with fever and medically indicated blood tests. Fever is defined as body temperature > 38°C measured at the emergency unit.

Exclusion Criteria

No medically indicated blood tests at the emergency unit.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Copeptin serum level in children with febrile seizures presenting at our emergency ward compared to children with fever but without seizures

Secondary Outcome Measures

Name	Time	Method
1) Copeptin serum level after febrile seizures compared to cerebral seizures without fever <br>2) Blood pH in all patients compared to type of seizures and value of copeptin<br>3) Level of von Willebrand-factor and von Willebrand-multimers as well as von Willebrand collagen binding activity in children with febrile seizures compared to children with fever but without seizuers