NCT07121387已完成不适用
A Real-World Retrospective Cohort Analysis of SMARCA4-Deficient Advanced Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China1 个研究点 分布在 1 个国家目标入组 221 人开始时间: 2020年1月1日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 221
- 试验地点
- 1
- 主要终点
- Progression-free survival (PFS)
研究概览
简要总结
This is a single-center retrospective analysis to explore the clinical characteristics, therapeutic efficacy, and tumor immune microenvironment of SMARCA4-deficient advanced non-small-cell lung cancer (NSCLC).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with stage III-IV NSCLC according to the American Joint Committee on Cancer staging criteria (7th edition);
- •Lesions are measurable according to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1;
- •Receiving first-line immunotherapy or chemotherapy as anti-tumor treatment.
排除标准
- •SMARCA4 gene test was not performed;
- •Not receive treatment;
- •Lost to follow-up after one treatment cycle.
结局指标
主要结局
Progression-free survival (PFS)
时间窗: 5 years
Time from the beginning of first-line therapy to the first progression (PD) in patients with lung cancer
次要结局
- Overall survival (OS)(5 years)
- Objective Response Rate (ORR)(5 years)
- Disease control rate (DCR)(5 years)
研究者
Yayi He
Professor
Shanghai Pulmonary Hospital, Shanghai, China
研究点 (1)
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