Comparing the effects of sitagliptin and empagliflozin on blood glucose , lipid profiles, blood pressure and body mass index in type2 dibetics patients treated with Metformi
Phase 3
Recruiting
- Conditions
- Type 2 diabetes.Type 2 diabetes mellitus with hyperosmolarity
- Registration Number
- IRCT20191231045959N1
- Lead Sponsor
- Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Treated with metformin or metformin in combination with sulfonylureas
HbA1C between 7 and 9 percent.
Exclusion Criteria
Having any cardiovascular, inflammatory, autoimmune disease
Pregnancy and lactation
Active Liver disease
Advanced Renal failure
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood Suger. Timepoint: Baseline and 3 months after the treatment. Method of measurement: Blood Test.;Systolic and diastolic blood pressure. Timepoint: Baseline and 3 months after the treatment. Method of measurement: Blood Test.;Lipid Profile. Timepoint: Baseline and 3 months after the treatment. Method of measurement: Blood Test.;Body Mass Index. Timepoint: Baseline and 3 months after the treatment. Method of measurement: Weight.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie sitagliptin and empagliflozin's effects on glucose regulation in type 2 diabetes patients on metformin?
How does empagliflozin compare to sitagliptin in improving cardiometabolic outcomes in metformin-treated type 2 diabetes mellitus patients?
Which biomarkers predict differential response to DPP-4 inhibition (sitagliptin) versus SGLT2 inhibition (empagliflozin) in type 2 diabetes?
What are the adverse event profiles of sitagliptin and empagliflozin when combined with metformin in hyperglycemic type 2 diabetes patients?
How do combination therapies of SGLT2 inhibitors and DPP-4 inhibitors compare to monotherapy in managing hyperosmolar type 2 diabetes mellitus?