Exercise and Systemic Lupus Erythematosus
Not Applicable
- Conditions
- Systemic Lupus Erythematosus
- Interventions
- Behavioral: Exercise training
- Registration Number
- NCT01515163
- Lead Sponsor
- University of Sao Paulo
- Brief Summary
The investigators hypothesize that a three-month aerobic exercise training program will positively affect the lipid profile, insulin sensitivity , cytokine profile, the cardiovascular parameters and muscle strength in SLE patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 90
Inclusion Criteria
- Age between 7 and 40 years
- SLEDAI ≤ 4
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Exclusion Criteria
- Cardiovascular dysfunction
- Rhythm and conduction disorders
- Musculoskeletal disturbances
- Kidney and pulmonary involvements
- Peripheral neuropathy
- Use of tobacco
- Treatment with lipid-lowering or hypoglycemic drugs
- Fibromyalgia
- Use of chronotropic or antihypertensive drugs
- Physically active subjects
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Exercise Exercise training 3-month exercise training program Healthy control Exercise training -
- Primary Outcome Measures
Name Time Method Lipid profile - Plasma levels of total cholesterol (mg/dl), VLDL-chol (mg/dl) HDL-chol (mg/dl), LDL-chol (mg/dl), triglycerides (mg/dl), Apolipoprotein AI and AII (mg/dl) and Apolipoprotein B (mg/dl) 3 months Insulin sensitivity as measured by the Hyperinsulinemic-Euglycemic Clamp 3 months Cytokine response - Plasma levels of TNF-α (pg/ml), IL-6 (pg/ml), IFN-type I (pg/ml), IL-10 (pg/ml)and IL-1ra (pg/ml) 3 months
- Secondary Outcome Measures
Name Time Method Cardiovascular parameters 3 months Aerobic capacity, chronotropic function
Muscle Strength 3 months Upper and Lower-body muscle strength will be assessed by a 1-RM (repetition maximum) protocol
Trial Locations
- Locations (1)
University of Sao Paulo
🇧🇷Sao Paulo, SP, Brazil