Preventive Antibiotic Serum Levels During Caesarean Section
试验速览
- 阶段
- 3 期
- 入组人数
- 250
- 主要终点
- Blood antibiotic levels
研究概览
简要总结
Background
Preventive antibiotic treatment before performing invasive procedures is a basic element in preventing infections. The essence of preventive antibiotic treatment is strengthening the defense mechanisms of the immune system by preserving a certain drug levels in the blood. The timing of giving the antibiotics is very important. Several research groups have tried to check the levels of Cefazolin (the most common antibiotics in the field of obstetrics) in serum and adipose tissue in women during cesarean. These groups presented conflicting research results.
OBJECTIVE
This study will discuss the preventive antibiotic treatment levels accepted prior cesareans, to determine:
- What are the factors affecting the level of drug in the blood?
- Is there a fixed time which beyond it, blood drug levels are below the MIC(Minimal Inhibitory Concentration)?
- Is the provision of usual preventive care also addresses the situations of metabolic disorder?
详细描述
Background
Preventive antibiotic treatment before performing invasive procedures is a basic element in preventing infections. The essence of preventive antibiotic treatment is strengthening the defense mechanisms of the immune system by preserving a certain drug levels in the blood. The timing of giving the antibiotics is very important. Several research groups have tried to check the levels of Cefazolin (the most common antibiotics in the field of obstetrics) in serum and adipose tissue in women during cesarean. These groups presented conflicting research results.
OBJECTIVE
This study will discuss the preventive antibiotic treatment levels accepted prior cesareans, to determine:
- What are the factors affecting the level of drug in the blood?
- Is there a fixed time which beyond it, blood drug levels are below the MIC(Minimal Inhibitory Concentration)?
- Is the provision of usual preventive care also addresses the situations of metabolic disorder?
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Gestational age of 37 weeks and above.
- •Women who arrive to elective cesareans.
- •Age of women: 18-50 years old.
排除标准
- •Suspected clinical / laboratory active infection
- •urgent surgery
- •Sensitivity to penicillin or cephalosporins antibiotics that requires antibiotics change.
- •Women who received the week before surgery antibiotic treatment
研究组 & 干预措施
cesarean in different indications
Women that are about to undergo an elective cesarean in different indications.
干预措施: Blood samples. (Procedure)
cesarean in different indications
Women that are about to undergo an elective cesarean in different indications.
干预措施: Cefazolin (Drug)
结局指标
主要结局
Blood antibiotic levels
时间窗: 30 min- 2 hours.
Blood MIC(Minimal Inhibitory Concentration) levels of antibiotic will be checked at first incision and at the time of closing surgery.
次要结局
未报告次要终点