Retrospective Study of Patients with Acute Presentation for Asthma to an Emergency Department in UK (RAPAE)

Not yet recruiting

• Conditions: Asthma Acute

• Registration Number: NCT06360185
• Lead Sponsor: Norfolk and Norwich University Hospitals NHS Foundation Trust

Brief Summary

Study team will obtain a list of all patients who have been seen in A+E over the past 6 years with a discharge diagnosis of asthma. Their history will be reviewed from their A+E notes. Team will obtain weight and height from Electronic prescribing tool and will obtain compliance information and past medical history from participant's GP records. Team will use participant's postcode to word out socio economic status quintile using office of national statistics tool. The following information will be taken from hospital documentation and from GP records.

Detailed Description

1. How many previous admissions in past one year (12 months)

2. How many presentations to A+E in previous one year (12 months)

3. Diagnosis not confirmed therefore not on any ICS

4. Poor compliance (less than 75% of ICS and/or LABA and/or LAMA and/or leukotriene prescriptions picked up in past year)

5. Recent presentation and maintenance therapy not increased (primary care or secondary care issue)

6. Is patient overweight BMI

7. Is patient on hormonal therapy, OCP, HRT, male hormones

8. Social class quintile from post code of address using ONS calculator

9. Ethnically diverse (see appendix)

10. First Eosinophil count on index admission

11. Highest eosinophil count in past (ever) and date

12. Treatment for diabetes type 2

13. Treatment for diabetes type 1

14. Treatment for hypertension

15. Smoker ever (pack year) when gave up__________

After obtaining this information study team will use simple statistical methods such as frequency and associations with confidence intervals to investigate which factors are associated with frequency of presentation to A+E. They will ascertain the frequency of patients who are on maximum therapy and may benefit from biological therapy, especially if they have raised eosinophils in the past year.

Study Timeline

• Study First Submitted: 2023-12-15
• Status Verified: 2024-03
• Study First Submitted QC: 2024-04-10
• Study First Posted: 2024-04-11
• Last Update Submitted: 2025-02-25
• Last Update Posted: 2025-02-27
• Study Start: 2025-12
• Primary Completion: 2027-12-01
• Study Completion: 2027-12-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• All Asthmatics patients who attend Emergency department over 5 years

Exclusion Criteria

• None Asthmatics.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in body height	5 years	Information will be taken from hospital documentation and from GP records.
Change in body weight	5 years	Information will be taken from hospital documentation and from GP records.