Development and validation of Transcranial Infrared Laser Therapy prototype on cognitive function, quality of life in elderly population

Design and Development of Transcranial Infra-Red Laser Therapy: The prototype system is currently based on infrared lasers using a wavelength of 810 nm. This wavelength has recently been proven one of the best for transcranial laser Stimulation. By comparing the fluence distribution, penetration depth, and the intensity of the laser-tissue interaction, it is found that 810 and 660 nm performed much better than other wavelengths. The proposed laser helmet or transcranial infra-red laser therapy prototype will have 35 active lasers using the parameters Indicated. The instrument will be developed in collaboration with industry partner Techno med Electronics. The duration of the stimulation will be 20 min.

Then, two sensors will be applied in the frontal area on the right and left sides of the brain of a healthy volunteer. To minimize the influence of external light, the head in this area will be covered with an elastic band during the recording and stimulation procedure. After a resting time of 15 min, the laser stimulation will be started.

The laser helmet will be placed on the skull and treated for a minimum of 20-minute duration for five weeks. A total of 20 participants will be recruited mainly through the screening procedure. For the cognitive function study, there will be 20 participants (10 males and ten postmenopausal females) aged 60–80 with self-reported subjective memory complaints. Our strategy will focus on cognitively at-risk adults and exclude participants with already established cardiovascular disease or dementia. Other exclusion criteria will be current pregnancy, prior institutionalization, diagnosis of psychotic disorder, or history of violent behavior. After obtaining the institutional Ethics Clearance and informed consent, participants will be recruited for the study.

The consent form explained the safety procedures used in the operation of the laser throughout the treatment sessions. Separate consent will be sought for participants who participated in the neural studies. Once the procedure and rationale of the study are made clear to the participant, Trans Cranial Infrared Laser stimulation —TILS will be administered daily for a 20-minute duration and a minimum of 5 sessions per week for the five-week  duration.