The Comparison of the Effect of Different Oxytocin Administrations on the Blood Loss During Cesarean Delivery: a Randomised Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 101
- 试验地点
- 2
- 主要终点
- blood loss during elective cesarean section
研究概览
简要总结
This study compares the effect of starting intravenous oxytocin infusion early before uterine incision versus late after umbilical cord clamping on the blood loss during elective cesarean section
详细描述
Postpartum hemorrhage (PPH) is still the major cause of maternal morbidity and mortality worldwide contributing to nearly 25% of direct maternal deaths. The average blood loss during cesarean section is 1000 ml which is nearly double the blood loss during vaginal delivery. Worldwide, the most commonly used uterotonic for the prevention of PPH is oxytocin. Several regimens of oxytocin have been tested during cesarean section with variable wanted (uterotonic) and unwanted (cardiovascular) effects. In the current study, we tested the hypothesis that initiating IV oxytocin infusion earlier before uterine incision would induce a rapid acceptable uterine contraction and minimize the intraoperative blood loss than the same dose administered after delivery of the fetus.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •single fetus at term >37 weeks of gestational age
排除标准
- •history of previous cesarean section
- •history of previous uterine surgery
- •multiple gestation, placenta previa, polyhydramnious, fetal macrosomia
- •women at high risk for uterine atony such as anemia (Hb < 8 gm/dL)
- •uterine atony history
- •gestational diabetes mellitus, gestational hypertension, preeclampsia, current or previous history of heart disease, liver, renal disorders or known coagulopath
研究组 & 干预措施
before uterine incision oxytocin group
IV infusion of 20 IU of oxytocin started before uterine incision
干预措施: before uterine incision oxytocin (Other)
after clamping the umbilical cord oxytocin group
IV infusion of 20 IU of oxytocin started immediately after clamping the umbilical cord
干预措施: after clamping the umbilical cord oxytocin (Other)
结局指标
主要结局
blood loss during elective cesarean section
时间窗: 2 hours
The intraoperative blood loss will be measured by adding the volume of the suction bottle with the blood soaked sponges (know dry weight). The blood loss was estimated after excluded amniotic fluid volume in the suction bottle in each case
次要结局
- postoperative blood loss(24 hours)