Intra-Aortic Balloon Counterpulsation in Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock - The Prospective, Randomised IABP SHOCK Trial for Attenuation of Multi-Organ Dysfunction Syndrome
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Myocardial Infarction
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- APACHE II SCORE
- Status
- Completed
- Last Updated
- 19 years ago
Overview
Brief Summary
The role of intra aortic balloon counterpulsation in patients experiencing acute myocardial infarction with shock is not established. We hypothesised that use of such a device would lead to improved outcomes in these patients.
Detailed Description
Patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) with cardiogenic shock (CS) are often treated with Intra-aortic balloon pump counterpulsation (IABP) although the evidence to support this is limited. We conducted a prospective, randomised clinical trial, of IABP as an addition to PCI centred therapy, in patients with AMI complicated by CS. 45 patients with AMI and CS undergoing PCI were randomised to care with or without IABP. Over 4 days, APACHE II scores, haemodynamic parameters, inflammatory markers and BNP levels were collected to assess the impact of IABP treatment on CS triggered multi organ dysfunction syndrome (MODS).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Acute myocardial infarction
- •Cardiogenic shock
Exclusion Criteria
- •Absent peripheral pulses
- •Mechanical complications of myocardial infarction
Outcomes
Primary Outcomes
APACHE II SCORE
Time Frame: 4 days
Secondary Outcomes
- Haemodynamic state(4 days)
- BNP levels(4 days)
- Inflammatory activation(4 days)
- Mortality(4 days)