NCT00754429已完成4 期
The Effect of Losartan Versus Amlodipine-based Antihypertensive Therapy on Atherosclerotic Inflammatory Markers and Cerebrovascular Regulation in Ischemic Stroke Patients
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 40
- 主要终点
- MCAFV and TCD for measuring cerebral autoregulatory indices at week 0, week 6, week 18 and week 30.
研究概览
简要总结
To compare the effect of losartan vs amlodipine-based antihypertensive therapy on atherosclerotic inflammatory markers and cerebrovascular regulation in Ischemic stroke patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient With Tia Or Ischemic Stroke (Event Has Occurred More Thaan 4 Weeks But Less Than 24 Weeks, And Modified Rankin'S Scale, Mrs<=3) With Mild To Moderate Hypertension
- •Patient Has No Other Active Medical Problem, Which Might Of Itself Or By This Treatment Significantly Affect The Patient's Blood Pressure
- •The Blood Level Of Hscrp>0.2 Ng/Dl By Two Measurements Performed Respectively One-Week Apart
排除标准
- •Patients With Cardiac Arrhythmia
- •Diabetes Mellitus
- •Patient With Other Active Inflammatory Diseases Such As Rheumatoid Disease, Fever And Systemic Infection Which Will Confound The Level Of Serum CRP
- •Patients With Known Intolerance, Contraindication Or Hypersensitivity To Losartan, Amlodipine and Hydrochlorothiazide
- •Patient With Myocardial Infarction Within The Recent Three Months
- •Anatomy Abnormality Which Results In Poor Bilateral Temporal Acoustic Windows Which Prevent TCD Procedure
- •Patient Who Requires Continuous Medication With Alpha Blocking Agents
- •Concurrent Usage Of Acei
- •Poor Mental Function Or Any Other Reason To Expect Difficulty In Meeting The Requirements Of The Study
- •Concurrent Treatment With Other Lipid-Lowering Drug
- •Childbearing Potential Women Not Undergoing Adequate Contraceptive Control
研究组 & 干预措施
A
Experimental
Losartan 50mg qd for 30 weeks, if blood pressure > 140/90, or mean arterial Bp ≧ 15% of baseline, then add on diuretics.
干预措施: losartan (Drug)
B
Active Comparator
Amlodipine 5 mg q.d for 30 weeks, if blood pressure > 140/90, or mean arterial Bp ≧ 15% of baseline, then add on diuretics.
干预措施: amlodipine (Drug)
结局指标
主要结局
MCAFV and TCD for measuring cerebral autoregulatory indices at week 0, week 6, week 18 and week 30.
时间窗: At week 0, week 6, week 18 and week 30.
次要结局
未报告次要终点
研究者
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