Growth Hormone Treatment of Children after Intrauterine Growth Retardation.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 170
研究概览
简要总结
Arends NJ, W VdL, Robben SG, Hokken-Koelega AC 2002 MRI findings of the pituitary gland in short children born small for gestational age (SGA) in comparison with growth hormone-deficient (GHD) children and children with normal stature. Clin Endocrinol (Oxf) 57:719-24
-Arends N, Johnston L, Hokken-Koelega A, et al. 2002 Polymorphism in the IGF-I gene: clinical relevance for short children born small for gestational age (SGA). J Clin Endocrinol Metab 87:2720
-Arends NJ, Boonstra VH, Mulder PG, et al. 2003 GH treatment and its effect on bone mineral density, bone maturation and growth in short children born small for gestational age: 3-year results of a randomized, controlled GH trial. Clin Endocrinol (Oxf) 59:779-87
-Boonstra V, van Pareren Y, Mulder P, Hokken-Koelega A 2003 Puberty in growth hormone-treated children born small for gestational age (SGA). J Clin Endocrinol Metab 88:5753-8
-Arends NJ, Boonstra VH, Hokken-Koelega AC 2004 Head circumference and body proportions before and during growth hormone treatment in short children who were born small for gestational age. Pediatrics 114:683-90
-Boonstra VH, Mulder PG, de Jong FH, Hokken-Koelega AC 2004 Serum dehydroepiandrosterone sulfate levels and pubarche in short children born small for gestational age before and during growth hormone treatment. J Clin Endocrinol Metab 89:712-7
--Arends NJ, Boonstra VH, Duivenvoorden HJ, Hofman PL, Cutfield WS, Hokken-Koelega AC 2005 Reduced insulin sensitivity and the presence of cardiovascular risk factors in short prepubertal children born small for gestational age (SGA). Clin Endocrinol (Oxf) 62:44-50
-Hokken-Koelega A, van Pareren Y, Arends N, Boonstra V. 2004 Efficacy and safety of long-term continuous growth hormone treatment of children born small for gestational age.
Horm Res. 62 Suppl 3:149-54. Review. -Hokken-Koelega AC, De Waal WJ, Sas TC, Van Pareren Y, Arends NJ. Small for gestational age (SGA): endocrine and metabolic consequences and effects of growth hormone treatment. 2004 J Pediatr Endocrinol Metab. Mar;17 Suppl 3:463-9.
-Hokken-Koelega AC, van Pareren Y, Sas T, Arends N. 2003 Final height data, body composition and glucose metabolism in growth hormone-treated short children born small for gestational age.Horm Res. ;60 Suppl 3:113-4.
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1. Birth weight < P3 for gestational age (according to Usher and Mc Lean);
- •2. Neonatal period without signs of severe asphyxia (defined as Apgar score < 3 after 5 minutes), without signs of chronic lung disease (such as bronchopulmonary dysplasia);
排除标准
- •1. Any endocrine or metabolic disorder such as diabetes mellitus, diabetes insipidus, hypothyroidism or inborn errors of metabolism, except of GHD;
- •2. Disorders of genito-urinary tract, cardiopulmonary or gastrointestinal tract, or nervous systems, nutritional and/or vitamin deficiencies;