Investigation of the Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Thessaly
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Anti-inflammatory effects
Study Overview
Brief Summary
The purpose of this study is to investigate the possible antioxidant and anti-inflammatory effects of yogurt enriched with polyphenols after 2-week consumption by healthy individuals.
Detailed Description
Eighteen healthy adult volunteers of both sexes consumed yogurt (400g per day) enriched with polyphenols (10mg/100g yogurt) or yogurt (400g per day) not enriched with polyphenols for two weeks in a double-blind, crossover, randomized manner.There was a washout period of at least 10 days. Physiological data and blood samples were collected before and after consumption of each yogurt.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Triple (Participant, Care Provider, Investigator)
Eligibility Criteria
- Ages
- 20 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy individuals
- •Non-smokers
Exclusion Criteria
- •Current use of dietary supplements or drugs
- •Metabolic disease
- •Lactose intolerance
- •Pregnant, pregnancy intention or breast feeding
Arms & Interventions
Yogurt enriched with polyphenols
Two yogurts (400g) enriched with polyphenols (10mg/100g yogurt) per day, for two weeks.
Intervention: Yogurt enriched with polyphenols (Other)
Yogurt not enriched with polyphenols
Two yogurts (400g) not enriched with polyphenols per day, for two weeks.
Intervention: Yogurt not enriched with polyphenols (Other)
Outcomes
Primary Outcomes
Anti-inflammatory effects
Time Frame: Two weeks
Indices of inflammation in blood
Antioxidant effects
Time Frame: Two weeks
Indices of blood antioxidant status
Secondary Outcomes
- Total cholesterol levels(Two weeks)
- Body composition(Two weeks)
- Hydration(Two weeks)
- Resting heart rate(Two weeks)
- Blood glucose levels(Two weeks)
- High Density Lipoprotein cholesterol levels(Two weeks)
- Blood pressure(Two weeks)
- Triglyceride levels(Two weeks)
Investigators
Athanasios Z. Jamurtas
Associate Professor
University of Thessaly