The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation

Phase 4

Completed

• Conditions: Cervical Disc Herniation; Cervical Spinal Stenosis; Cervical Spine Damage

• Registration Number: NCT01052324
• Lead Sponsor: Yonsei University

Brief Summary

Remifentanil provides analgesia, suppresses airway reflex, has little effect on cognitive function. It can be used for conscious sedation during awake nasotracheal fiberoptic intubation. Target-controlled infusion is more reliable technique for maintaining optimal infusion rate than manual controlled infusion. The aim of this study is to determine the effect site concentration of remifentanil for successful conscious sedation during awake nasotracheal fiberoptic intubation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-01-11
• Study First Submitted QC: 2010-01-19
• Study First Posted: 2010-01-20
• Study Start: 2010-03
• Primary Completion: 2010-11
• Study Completion: 2010-11
• Status Verified: 2011-05
• Last Update Submitted: 2011-05-12
• Last Update Posted: 2011-05-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 19

Inclusion Criteria

• Patients undergoing cervical spine surgery
• Age 20-65
• American Society of Anesthesiologists physical status classification I or II

Exclusion Criteria

• Patients' refusal
• allergy to any drug used
• unable to cooperate
• Severe hepatic or renal disease
• coagulation disorder
• chronic use of opioids or sedatives
• increase risk of pulmonary aspiration.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
EC50 of remifentanil for preventing persistent cough and defensive movement using Dixon's up-and-down method

Trial Locations

Locations (1)

Severance Hospital; 🇰🇷 Seoul, Korea, Republic of