Efficacy of Artemether-Lumefantrine and Amodiaquine-Artesunate for treatment of Uncomplicated Malaria in Children in Uganda

Not Applicable

• Conditions: ncomplicated falciparum malaria in children; Uncomplicated falciparum malaria in children; Infection - Other infectious diseases

• Registration Number: ACTRN12613000408785
• Lead Sponsor: ganda National Malaria COntrol Program, Ministry of Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-04-15
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

Age 6-59 months
Uncomplicated malaria due to P. falciparum mono-infection with parasite density between 2000 and 200,000 /microliter of blood
Fever ( > 37.5 degrees Celsius axillary) or history of fever in the previous 24 hours
Provision of informed consent and ability to participate in 28-day follow-up (patient has easy access to health unit)
Not previously enrolled in this study

Exclusion Criteria

Weight less than 5 kg
History of serius side effects to study medications
Concomitnt febrile illness in addition to malaria
Danger and signs or evidence of severe malaria
Severe malnutiriton
Regular medication which may interfere with the antimalarial pharmacokinetic
History of hypersensitivity reactions or contraindications to any of the medicine(s) being tested.

Study & Design

• Study Type: Interventional
• Study Design: Not specified