The Effect of Esmolol on Patients With Sepsis
- Registration Number
- NCT04537767
- Lead Sponsor
- Shanghai Zhongshan Hospital
- Brief Summary
The investigators conduct an RCT to explore the efficacy of esmolol in patients with septic shock and sepsis.
- Detailed Description
Severe sepsis, septic shock, and their complications have become the major healthcare problem that affects millions of people each year, resulting in high mortality rates. Septic responses have an extremely complex chain of events including inflammatory and anti-inflammatory processes, humoral and cellular reactions, and cardiocirculatory abnormalities. Esmolol may have some potential in treating septic shock and sepsis. The investigators conduct an RCT to explore the efficacy of esmolol in patients with septic shock and sepsis.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 120
- sepsis patients
- HR>100bpm 6h after admission
- with CVC and ScvO2>65%
- age <18 years,
- used β-blocker before,
- cardiac dysrhythmias,
- need for an inotropic agent,
- valvular heart disease,
- hemoglobin>6g/L
- pregnancy.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description control group Placebo Patients randomly assigned to the control group were treated with placebo. ES group Esmolol Patients randomly assigned to the ES group were treated with esmolol to control the heart rate to the target range.
- Primary Outcome Measures
Name Time Method REE Day 7 after enrollment Resting energy expenditure
- Secondary Outcome Measures
Name Time Method HR control rate 24 hours after enrollment target heart rate control rate
O2ER Day 1/3/7 after enrollment oxygen extraction rate
28-day mortality rate Day 28 after enrollment 28-day mortality rate
Vasoactive drug administration dose Day 1/3/7 after enrollment Vasoactive drug administration dose
Concentration of Lac Day 1/3/7 after enrollment Concentration of lactic acid