Renoprotective Effect of Nisoldipine and Lisinopril in Type 1 Diabetic Nephropathy
Phase 4
Completed
- Conditions
- Diabetic Nephropathy
- Registration Number
- NCT00311870
- Lead Sponsor
- Steno Diabetes Center Copenhagen
- Brief Summary
The aim of the study was to compare the renoprotective effect of a long acting calcium antagonist (nisoldipine) with an angiotensin converting enzyme inhibitor (lisinopril)in type 1 diabetic patients with diabetic kidney disease. In total, 51 patients were randomised to treatment with one of these drugs for 4 years. Changes in kidney function, blood pressure and urinary excretion of albumin were measured every 6 months
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 52
Inclusion Criteria
- diabetic nephropathy, type 1 diabetes, hypertension
Exclusion Criteria
- child bearing potential, non-diabetic kidney disease, malignancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method change in glomerular filtration rate from study start to study end
- Secondary Outcome Measures
Name Time Method change in urinary albumin excretion rate blood pressure response
Trial Locations
- Locations (1)
Steno Diabetes Center
🇩🇰Gentofte, Denmark