Phase II Multicenter Study in the Preoperative Treatment of Gastric Adenocarcinoma Consisting of Chemotherapy Using Docetaxel-cisplatin-5FU + Lenograstim Followed by Chemoradiation Based 5FU and Oxaliplatin
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Histological response rate on surgical specimen after chemotherapy and chemoradiotherapy preoperative
研究概览
简要总结
It is estimated to 7300 the number of new cases of gastric cancer each year in France.
According to a randomized trial comparing 3 cycles of ECF (epirubicin, cisplatin, 5FU) administered before surgery and 3 cycles after surgery with surgery alone in adenocarcinoma of the stomach and lower esophagus, clinical and experimental data are the neoadjuvant chemotherapy is a new standard treatment for operable gastric cancer. This treatment with a median survival of more than 3 years to obtain a hazard ratio of 0.75 in favor of chemotherapy arm (p = 0.009). The 5-year survival being 36% for patients treated with chemotherapy versus 23% for surgery alone. Progression-free survival was also significantly prolonged with a hazard ratio of 0.66.
The proposed clinical study by Ajani et al shows that the combination of Docetaxel with the schema Cisplatin - 5FU provides greater clinical benefit and induces to consider the triple combination as a reference treatment in metastatic gastric cancer in patients under 65 years.
Preoperative radiochemotherapy is expected to increase the rate of curative resections, reduce gastrointestinal and hematologic toxicity.
Two studies evaluating the feasibility of preoperative RTCT in operable gastric adenocarcinoma with continuous 5GU (+ or - paclitaxel) and 45 Gy are available and the combination 5FU oxaliplatin has been assessed in the esophagus and rectum tumors.
The NESC study, Phase II, proposes the following schema: 2 cycles of chemotherapy with Docetaxel - Cisplatin - 5FU then preoperative chemoradiation with oxaliplatin - continuous 5FU and radiotherapy in locally advanced gastric adenocarcinoma stage III and IV non-metastatic administered before surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female patients, Age: 18 to 65
- •ECOG performance status of ≤ 1
- •Histological documentation of the gastric adenocarcinoma. An extension will be admitted to the omentum
- •Adenocarcinoma of the stomach according to staging classification TNM Scannographic: T2bN0, T2bN1, T3NO T3N +, T4N0, and T4N + M0 (cardia, Siewert II, III, fundus, body, antrum) performed by ultrasonography and CT Scan. Optional : laparoscopy
- •A positive peritoneal cytology is not a disqualifying factor if there is no macroscopic carcinomatosis
- •Absence of previous abdominal irradiation above the 5th sacral vertebra (in the liver, pancreas, spleen, or mediastinal lodge)
- •Loss of weight less than 15% over the base weight before diagnosis
- •No psychological, familial, sociological or geographical condition that may affect compliance and adherence to treatment, patient monitoring or understanding of the study.
- •Signed informed consent obtained before any study specific procedures.
- •Food Consumption> 1000 calories / day whatever the mode of administration (enteral or parenteral)
- •Laboratory test conducted within one week of starting to study treatment:
- •Absolute neutrophil count > 1500/mm3
- •Platelet count > 100 000/mm3
- •Total bilirubin <2 mg/dL
- •Serum creatinine <13 mg/dL or creatinine clearance > 40 ml/min
- •Hemoglobin (Hgb) ≥ 10 g/dL (Hemoglobin transfusion if necessary)
- •ALT / AST <1.5 x ULN
- •PTT ≥ 60 %
- •Life expectancy of at least 3 months
排除标准
- •Peripheral sensory neuropathy ≥ grade 1 (according to CTCAE version 3.0).
- •Myocardial infarction, stroke or pulmonary embolism, unstable angina less than 6 months before start of study drug.
- •Uncontrolled infection
- •Pregnant or breast-feeding patients. Women of childbearing potential must have a pregnancy test performed.
- •Prior treatment for gastric adenocarcinoma
- •Lower limbs arteritis (≥ stage II according the Leriche and Fontain classification)
- •Patient participating in another clinical trial or already receiving other anti-cancer treatment
- •Concomitant treatment with a phenytoin
- •Known previous / current malignancy within the last 5 years except for non-melanoma skin, non-metastatic prostate carcinoma and cervival carcinoma in situ or superficial bladder carcinoma.
研究组 & 干预措施
Single arm study
Docetaxel - Cisplatine - 5FU 2 cycles of Docetaxel - Cisplatine - 5 FU
Radiation: Radiation of 45 Grays on 5 weeks Radiochemotherapy with Oxaliplatine (J1, J15 et J29) - 5FU on 5 weeks
干预措施: Docetaxel - Cisplatine - 5FU (Drug)
Single arm study
Docetaxel - Cisplatine - 5FU 2 cycles of Docetaxel - Cisplatine - 5 FU
Radiation: Radiation of 45 Grays on 5 weeks Radiochemotherapy with Oxaliplatine (J1, J15 et J29) - 5FU on 5 weeks
干预措施: Radiation of 45 Grays on 5 weeks (Radiation)
结局指标
主要结局
Histological response rate on surgical specimen after chemotherapy and chemoradiotherapy preoperative
时间窗: 1year
Histological response rate
次要结局
未报告次要终点
研究者
Recherche clinique
Doctor Laurent Mineur
Institut Sainte Catherine