Study of autologous adipose derived stromal cell transplantation in women with POF
Not Applicable
- Conditions
- Premature ovarian failure.Premature menopause NOS
- Registration Number
- IRCT201510271031N18
- Lead Sponsor
- Royan Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 9
Inclusion Criteria
Female; Age: 20-39; FSH>20; One year after POF diagnose; Normal karyotype
Exclusion criteria: Liposuction contraindication; Thyroid dysfunction; Immune system disease; Past history of cancer; Chemotherapy; Radiotherapy; HIV+; Hepatitis B or C; Severe endometriosis
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method umber of patient with adverse event. Timepoint: One year after transplantation. Method of measurement: Adverse event report form.
- Secondary Outcome Measures
Name Time Method umber of antral follicle. Timepoint: Base line,1,2,4,8 and 12 weeks, 6 month and 1 year after transplantation. Method of measurement: Sonography.;AMH serum level. Timepoint: Base line and 1 year after transplantation. Method of measurement: Laboratory test.;FSH serum level. Timepoint: Base line,1,2,4,8 and 12 weeks, 6 month and 1 year after transplantation. Method of measurement: Laboratory test.;Antral follicle volume. Timepoint: Base line,1,2,4,8 and 12 weeks, 6 month and 1 year after transplantation. Method of measurement: Sonography.;Menstruation recurrence rate. Timepoint: Base line,1,2,4,8 and 12 weeks, 6 month and 1 year after transplantation. Method of measurement: Questionary.;Pregnancy rate. Timepoint: One year after transplantation. Method of measurement: Beta-hCG serum level.