Periodontitis and obesity

Not Applicable

Completed

• Conditions: Obesity and chronic periodontitis; Oral Health; Chronic periodontitis

• Registration Number: ISRCTN14838813
• Lead Sponsor: Joint UCLH/UCL Biomedical Research Unit

Brief Summary

2020 Results article in https://pubmed.ncbi.nlm.nih.gov/31994205/ (added 04/03/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2013-01-17
• Study Start: 2018-06-12
• Last Update Posted: 14 March 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

1. Individuals at least 35 years of age and in good general health
2. Have BMI between 20-24.9 (WHO Normal) or BMI =30 (WHO Obese)
3. Participants must have a minimum of 15 natural teeth
4. Participants must have severe periodontal disease defined as >30% sites with PPD =5 attachment loss (1998 AAP classification)
5. Participants must voluntarily agree to sign the consent form

Exclusion Criteria

1. BMI between 25-29.9 (WHO overweight)
2. Current smokers or former smokers who have smoked within the previous 5 years
3. History of diabetes
4. Uncontrolled or currently undergoing treatment for serious systemic medical conditions including hepatic disease, renal disease, transmittable diseases, cancer, or HIV
5. On chronic treatment (defined as 2 weeks or more) of antibiotic, anti-inflammatory or anticoagulant therapy during the month preceding the baseline exam
6. History of alcohol or drug abuse
7. Self reported pregnancy or lactation (this criterion is due to oral tissue changes related to pregnancy and nursing which can affect interpretation of study results)
8. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study
9. Participation in any other dental study concurrently

Study & Design

• Study Type: Observational
• Study Design: Not specified