The Metabolic Effect of Walnut Consumption in Healthy Men and Healthy Postmenopausal Women

Not Applicable

Completed

• Conditions: Healthy

• Registration Number: NCT01188902
• Lead Sponsor: Ludwig-Maximilians - University of Munich

Brief Summary

The objectives of the proposed study are to assess the effect of walnut consumption on parameters of lipid metabolism, glucose metabolism, incretins and adipokines, endothelial function and blood pressure in healthy men and healthy postmenopausal women

Detailed Description

Not available

Study Timeline

• Study Start: 2010-08
• Study First Submitted: 2010-08-25
• Study First Submitted QC: 2010-08-25
• Study First Posted: 2010-08-26
• Primary Completion: 2012-04
• Study Completion: 2012-08
• Status Verified: 2013-01
• Last Update Submitted: 2013-01-07
• Last Update Posted: 2013-01-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Postmenopausal healthy women and healthy men
• Age > 50 yrs

Exclusion Criteria

• Evidence of alcohol, tabacco or drug abuse
• Obesity ≥ 35 kg/m2
• Diabetes mellitus
• Hypertension
• LDL-cholesterol > 190 mg/dl, Triglycerides > 350 mg/dl
• History of atherosclerotic disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Fasting non-HDL-cholesterol	8 weeks

Secondary Outcome Measures

Name	Time	Method
area under the triglyceride curve (AUC-TG)	8 weeks	area under the plasma triglyceride concentration curve following a standardized oral fat challenge
incremental area under the triglyceride curve (iAUC-TG)	8 weeks	incremental area under the plasma triglyceride concentration curve following a standardized oral fat challenge
LDL-cholesterol	8 weeks	fasting plasma LDL-cholesterol concentration
HDL-cholesterol	8 weeks	fasting plasma HDL-cholesterol concentration
triglyceride	8 weeks	fasting plasma triglyceride concentration
glucose	8 weeks	fasting plasma glucose concentration
HOMA	8 weeks
insulin	8 weeks
HbA1c	8 weeks
area under the glucose curve (AUC-glucose)	8 weeks	area under the plasma glucose concentration curve following a standardized oral challenge
area under the insulin curve (AUC-insulin)	8 weeks	area under the plasma insulin concentration curve following a standardized oral challenge
endothelial function	8 weeks	Postprandial (mixed meal challenge) endothelial function (flow mediated dilatation, flow-independent dilatation)

Trial Locations

Locations (1)

Med Dept. 2 Grosshadern; 🇩🇪 Munich, Germany