NCT01188902已完成不适用
The Metabolic Effect of Walnut Consumption in Healthy Men and Healthy Postmenopausal Women
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Fasting non-HDL-cholesterol
研究概览
简要总结
The objectives of the proposed study are to assess the effect of walnut consumption on parameters of lipid metabolism, glucose metabolism, incretins and adipokines, endothelial function and blood pressure in healthy men and healthy postmenopausal women
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Postmenopausal healthy women and healthy men
- •Age > 50 yrs
排除标准
- •Evidence of alcohol, tabacco or drug abuse
- •Obesity ≥ 35 kg/m2
- •Diabetes mellitus
- •Hypertension
- •LDL-cholesterol > 190 mg/dl, Triglycerides > 350 mg/dl
- •History of atherosclerotic disease
研究组 & 干预措施
walnut
Experimental
western type diet with 48 g walnut per day
干预措施: walnut (Dietary Supplement)
control
No Intervention
结局指标
主要结局
Fasting non-HDL-cholesterol
时间窗: 8 weeks
次要结局
- area under the triglyceride curve (AUC-TG)(8 weeks)
- incremental area under the triglyceride curve (iAUC-TG)(8 weeks)
- LDL-cholesterol(8 weeks)
- HDL-cholesterol(8 weeks)
- triglyceride(8 weeks)
- glucose(8 weeks)
- HOMA(8 weeks)
- insulin(8 weeks)
- HbA1c(8 weeks)
- area under the glucose curve (AUC-glucose)(8 weeks)
- area under the insulin curve (AUC-insulin)(8 weeks)
- endothelial function(8 weeks)
研究者
Klaus Parhofer
Professor of Medicine
Ludwig-Maximilians - University of Munich
研究点 (1)
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