Is Pentoxifylline Able to Improve Olfactory Sensitivity?

Completed

• Conditions: Olfaction Disorders
• Interventions: Drug: Pentoxifylline retard 400mg

• Registration Number: NCT00660868
• Lead Sponsor: Technische Universität Dresden

Brief Summary

Signal processing in the olfactory neuron could be influenced by inhibition of enzymes like phosphodiesterase. Pentoxifylline is a unspecific phosphodiesterase inhibitor. The hypothesis is that pentoxifylline could lead to increased sensitivity to odors.

Detailed Description

Olfactory signal processing is conducted by a G-protein linked increase of intracellular concentration of adenosine 3´,5´-cyclic monophosphate (cAMP). In the cilia of olfactory sensory neurons (OSN) cAMP is degraded by phosphodiesterase 1C2 (PDE1C2). Inhibition of PDE1C2 could result in an increased response of OSN to chemical stimuli. Aim of the present prospective post-marketing surveillance study was to investigate the impact of pentoxifylline, an unspecific phosphodieasterase inhibitor, on olfactory function.

Study Timeline

• Study First Submitted: 2008-04-16
• Study First Submitted QC: 2008-04-16
• Study First Posted: 2008-04-17
• Study Start: 2009-11
• Primary Completion: 2016-01
• Study Completion: 2016-01
• Status Verified: 2016-02
• Last Update Submitted: 2016-02-04
• Last Update Posted: 2016-02-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

• hyposmic or functionally anosmic patients TDI-score <31
• age: 18-50 years
• odor threshold: better than 1
• cause of smell loss: post traumatic, postinflammatory, idiopathic

Exclusion Criteria

• normosmic patients,
• patients with contraindications for application of pentoxifylline
• patients that cannot give written agreement to the study
• patients under 18 years and over 50 years of age

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	Pentoxifylline retard 400mg	Patients with posttraumatic, idiopathic, and postinflammatory cause of smell loss; patients age between 18 and 50 years. Odor threshold better than 1.

Primary Outcome Measures

Name	Time	Method
TDI-score	at day 0 and follow up after 3 weeks

Secondary Outcome Measures

Name	Time	Method
odor threshold odor discrimination odor identification	at day 0 and at follow up after 3 weeks

Trial Locations

Locations (1)

Zentrum für Riechen und Schmecken, Universitäts- HNO- Klinik Dresden; 🇩🇪 Dresden, Germany