A Pilot, Randomised Controlled Study to evaluate whether the administration of enteral Ivabradine plus standard care reduces tachycardia in critically ill adult patients with septic shock compared to standard care alone.

Perioperative and Critical Care Research Monash Medical Centre0 个研究点目标入组 20 人开始时间: 2018年10月11日最近更新: 2019年9月30日

适应症

试验速览

暂无简介。

•Patients aged equal and/or older than18 years
•Septic shock as defined as
•oHypotension (mean arterial pressure < 65 mmHg) not respon-sive to fluid resuscitation
•oRequirements for vasopressors (noradrenaline, vasopressin, metaraminol, phenylephrine)
•oInfection of any source
•Sinus tachycardia with heart rate equal or greater than 100

•Exclusion criteria
•Acute heart failure as defined by the presence of cardiogenic shock or cardiogenic pulmonary edema
•Arrhythmmias include Atrial fibrillation (AF)
•Acute hepatic failure as defined by the development of severe acute liver injury with encephalopathy and impaired synthetic function (INR equal or greater than 1.5) in a patient with no pre-existing liver disease
•Decompensated chronic liver disease as defined by the presence of jaundice, ascites, variceal haemorrhage or hepatic encephalopathy in a patient with known liver cirrhosis
•Physician preference
•If the patient expected to die during this admission

发起方

Perioperative and Critical Care Research Monash Medical Centre