The effectiveness of manual lymphatic drainage in haemophilic arthropathy (HA)
Not Applicable
- Conditions
- D66D67Hereditary factor VIII deficiencyHereditary factor IX deficiency
- Registration Number
- DRKS00023198
- Lead Sponsor
- Hämophiliezentrum, Institut für Transfusionsmedizin, Medizinische Klinik III, Goethe Universitätsklinikum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 14
Inclusion Criteria
confirmed Haemophilie A/B diagnosis
--at least one Target Joint due to recurrent bleeding events
- informed consent
Exclusion Criteria
- age younger than 18 years
- no Haemophilia or no target joints defined
- no informed consent, incapable of giving consent
-any surgery in the last 6 weeks
- patients with decompensated right heart failure
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in subjective pain perception using the visual analog scale (VAS and hemophilia pain questionnaire) at four measuring points:<br>Time 0: before start of period I (group A: with MLD treatment, group B: without MLD treatment)<br>Time 1: after period I.<br>Time 2: after wash-out phase<br>Time point 3: after period II (group A: period without MLD treatment, group B: with MLD treatment)
- Secondary Outcome Measures
Name Time Method - Change in joint mobility (ROM, Range of Motion) using a goniometer<br>- Change in hemophilia joint score (HJHS, Haemophilia Health Joint Score)<br>- Change in surface temperature of a target joint (infrared thermography)<br>All measurements are taken at different times:<br>Time 0: before the start of period I (group A: with MLD treatment, group B: without MLD treatment)<br>Time 1: after period I.<br>Time 2: after wash-out phase<br>Time point 3: after period II (group A: period without MLD treatment, group B: with MLD treatment)