Assessment of Lung Mechanics in COVID-19 Acute Respiratory Distress Syndrome

• Conditions: Covid19; ARDS

• Registration Number: NCT04597853
• Lead Sponsor: University of Zurich

Brief Summary

This study is meant to assess the lung mechanics in SARS-CoV-2 induced acute respiratory failure. A precise characterisation of lung mechanics and heart-lung-interactions might allow a better understanding of SARS-CoV-2 induced acute respiratory failure and thus lead to better mechanical ventilation strategies.

This monocentric, observational study of critically ill COVID-19 patients in the ICU, will employ impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry as well as classic mechanical ventilation parameters to characterise the mechanical characteristics of the lung as well as the heart-lung interactions in SARS-CoV-2 induced acute respiratory failure.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-10-19
• Study First Submitted QC: 2020-10-21
• Study First Posted: 2020-10-22
• Study Start: 2021-03-01
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-05
• Last Update Posted: 2021-05-10
• Primary Completion: 2021-12-31
• Study Completion: 2022-03-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• SARS-CoV-2 infection
• Moderate to Severe ARDS after Berlin Classification at PEEP 5
• Admission to the Institute of Intensive Care of the University Hospital Zurich
• Invasive Mechanical Ventilation
• Signed Study Informed Consent or emergency procedure according to article 30 HFG

Exclusion Criteria

• Pregnant or breast feeding patients
• Age <18 years
• Presumed rejection of the study intervention

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
PEEP and time dependent change in dead space	Mixed Model Assessment of Dead Space over time until extubation (measurements every 2 days up to 90 days)	Change in Dead Space over the length of mechanical ventilation
Time dependent compliance change	Mixed Model Assessment of compliance over time until extubation (measurements every 2 days up to 90 days)	Compliance change over the length of mechanical ventilation
PEEP and time dependent change in shunt fraction	Mixed Model Assessment of shunt fraction over time until extubation (measurements every 2 days up to 90 days)	Change in shunt fraction over the length of mechanical ventilation

Trial Locations

Locations (1)

Institute of Intensive Care Medicine, University Hospital Zurich; 🇨🇭 Zurich, Switzerland