Assessment of Lung Mechanics in SARS-CoV-2/ COVID-19 Acute Respiratory Distress Syndrome: A Holistic, Longitudinal Analysis of the Lung-heart-ventilator Interaction
试验速览
- 阶段
- 不适用
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- PEEP and time dependent change in dead space
研究概览
简要总结
This study is meant to assess the lung mechanics in SARS-CoV-2 induced acute respiratory failure. A precise characterisation of lung mechanics and heart-lung-interactions might allow a better understanding of SARS-CoV-2 induced acute respiratory failure and thus lead to better mechanical ventilation strategies.
This monocentric, observational study of critically ill COVID-19 patients in the ICU, will employ impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry as well as classic mechanical ventilation parameters to characterise the mechanical characteristics of the lung as well as the heart-lung interactions in SARS-CoV-2 induced acute respiratory failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •SARS-CoV-2 infection
- •Moderate to Severe ARDS after Berlin Classification at PEEP 5
- •Admission to the Institute of Intensive Care of the University Hospital Zurich
- •Invasive Mechanical Ventilation
- •Signed Study Informed Consent or emergency procedure according to article 30 HFG
排除标准
- •Pregnant or breast feeding patients
- •Age <18 years
- •Presumed rejection of the study intervention
结局指标
主要结局
PEEP and time dependent change in dead space
时间窗: Mixed Model Assessment of Dead Space over time until extubation (measurements every 2 days up to 90 days)
Change in Dead Space over the length of mechanical ventilation
Time dependent compliance change
时间窗: Mixed Model Assessment of compliance over time until extubation (measurements every 2 days up to 90 days)
Compliance change over the length of mechanical ventilation
PEEP and time dependent change in shunt fraction
时间窗: Mixed Model Assessment of shunt fraction over time until extubation (measurements every 2 days up to 90 days)
Change in shunt fraction over the length of mechanical ventilation
次要结局
未报告次要终点