Assessment of Lung Mechanics in SARS-CoV-2/ COVID-19 Acute Respiratory Distress Syndrome: A Holistic, Longitudinal Analysis of the Lung-heart-ventilator Interaction
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Covid19
- Sponsor
- University of Zurich
- Enrollment
- 25
- Locations
- 1
- Primary Endpoint
- PEEP and time dependent change in dead space
- Last Updated
- 4 years ago
Overview
Brief Summary
This study is meant to assess the lung mechanics in SARS-CoV-2 induced acute respiratory failure. A precise characterisation of lung mechanics and heart-lung-interactions might allow a better understanding of SARS-CoV-2 induced acute respiratory failure and thus lead to better mechanical ventilation strategies.
This monocentric, observational study of critically ill COVID-19 patients in the ICU, will employ impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry as well as classic mechanical ventilation parameters to characterise the mechanical characteristics of the lung as well as the heart-lung interactions in SARS-CoV-2 induced acute respiratory failure.
Investigators
Eligibility Criteria
Inclusion Criteria
- •SARS-CoV-2 infection
- •Moderate to Severe ARDS after Berlin Classification at PEEP 5
- •Admission to the Institute of Intensive Care of the University Hospital Zurich
- •Invasive Mechanical Ventilation
- •Signed Study Informed Consent or emergency procedure according to article 30 HFG
Exclusion Criteria
- •Pregnant or breast feeding patients
- •Age \<18 years
- •Presumed rejection of the study intervention
Outcomes
Primary Outcomes
PEEP and time dependent change in dead space
Time Frame: Mixed Model Assessment of Dead Space over time until extubation (measurements every 2 days up to 90 days)
Change in Dead Space over the length of mechanical ventilation
Time dependent compliance change
Time Frame: Mixed Model Assessment of compliance over time until extubation (measurements every 2 days up to 90 days)
Compliance change over the length of mechanical ventilation
PEEP and time dependent change in shunt fraction
Time Frame: Mixed Model Assessment of shunt fraction over time until extubation (measurements every 2 days up to 90 days)
Change in shunt fraction over the length of mechanical ventilation