Incidence of Radiation-induced Hypothyroidism and Parathyroid Dysfunction Following Head and Neck Irradiation: A Single Center Analysis

Completed

• Conditions: Patients who diagnosed head and neck cancer and received curative irradiation as a part of treatment were evaluated serum thyroid and parathyroid functions; Radiation; Hypothyroidism; Parathyroid dysfunction

• Registration Number: TCTR20210204008
• Lead Sponsor: Faculty of Medicine, Chiang Mai University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2020-11-23
• Study Start: 2021-02-04
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

1.age 18 to 75 years old at the time of diagnosis
2.completed RT course at least 12 months before laboratory testing of thyroid and parathyroid function
3.treating as curative intent including chemotherapy
4.no distant metastasis
5.postoperative RT was allowed unless the operation was involved the thyroid gland
6.planning radiation treatment using 3D-CRT or IMRT/ IGRT with SIB
7.available of back up treatment plans

Exclusion Criteria

1.disease extending into hypothalamus-pituitary-thyroid axis or any intracranial involvement
2.radiation field involved pituitary fossa
3.pre-existing thyroid or pituitary disease
4.abnormal thyroid or parathyroid detected from imaging before RT
5.previous thyroid surgery
6.previous RT which RT field might include pituitary gland or lower neck
7.previous iodine radioisotope treatment
8.the patients who were not willing to participate the trial

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of hypothyroidism after head and neck irradiation at least 12 months before laboratory testing of thyroid function serum thyroid function and correlated with radiation painting to thyroid gland

Secondary Outcome Measures

Name	Time	Method
Incidence of parathyroid dysfunction after head and neck irradiation at least 12 months before laboratory testing of parathyroid function serum parathyroid function and correlated with radiation painting to parathyroid region