General anesthesia for bronchial thermoplasty in patients with severe, persistent asthma - description of a protocol

Not Applicable

Completed

• Conditions: Asthma; Bronchial thermoplasty; Anaesthesiology - Other anaesthesiology; Surgery - Other surgery; General Anesthesia; Respiratory - Asthma

• Registration Number: ACTRN12615001198516
• Lead Sponsor: CHU Dinant-Godinne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-11-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 4

Inclusion Criteria

Adults suffering from severe persistent asthma scheduled for bronchial thermoplasty under general anesthesia

Exclusion Criteria

Suspicion of pregnancy confirmed by beta HCG dosage

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Respiratory stability as assessed by tidal volume, peak inspiratory pressure, peripheral capillary oxygen saturation(SpO2), fraction of inspired oxygen(FiO2), partial pressure of oxygen in the arterial blood(PaO2), partial pressure of carbon dioxide in the arterial blood and end tidal carbon dioxide concentration(EtCO2)[At baseline and every 2 minutes intraoperatively for SpO2, FiO2, tidal volume, peak inspiratory pressure and EtCO2. At baseline and every 15 minutes intraoperatively for PaO2 et PaCO2];Operator satisfaction as assesed by the total duration of the thermoplasty session and the cumulated pause time needed for optimisation of patient’s respiratory status if desaturation, cough or air leaks occur.[From start of thermoplasty session as defined by the first delivery of the radiofrequency current to the first bronchus to treat to the end of the session defined by the last activation of the thermoplasty device.]

Secondary Outcome Measures

Name	Time	Method
Hemodynamic stability as assessed by heart rate and blood pressure measured invasively via a radial artery catheter.[At baseline and every 2 minutes intraoperatively. ];The need for bronchodilators as assessed by the total dose of Duovent and adrenaline aerosols[From arrival until 2 hours after arrival in the post anesthesia care unit.];Thoracic pain as assessed by Visual Analogue Scale[Every 5 minutes during the 2 hour stay in the Post Anesthesia Care Unit]