Effects of Pectin Supplementation in Diarrhea-predominant Irritable Bowel Syndrome
Phase 3
Completed
- Conditions
- Irritable Bowel Syndrome
- Registration Number
- NCT02270268
- Lead Sponsor
- Nanjing PLA General Hospital
- Brief Summary
The purpose of this study is to investigate the effect of pectin, a kind of soluble dietary fiber, on clinical symptoms, gut microbiota and the immune status in patients with diarrhea-predominant irritable bowel syndrome
- Detailed Description
Patients were randomized to receive either pectin or placebo. Treatment consisted of 6 weeks supplementation with pectin (fiber group) or placebo (maltodextrin). We evaluated the clinical symptoms, gut microbiota and the immune markers in two groups.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 114
Inclusion Criteria
- All patients(age≧18y)
- Admitted for diarrhea-predominant irritable bowel syndrome
Exclusion Criteria
- Mental disorders
- Cancer
- Inflammatory bowel disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method efficacy: change of stool frequency, faecal form and clinical symptoms score six weeks after inclusion change from baseline in stool frequency, faecal form (Bristol stool scale) and clinical symptoms score (7-point Likert scale) at six weeks
- Secondary Outcome Measures
Name Time Method efficacy: gut microbiota six weeks after inclusion real-time PCR
efficacy: cytokine ratios six weeks after inclusion Cytokine production