Forced Lefthandedness in Neonatal Brachial Plexus Palsy (NBPP) Children : is There a Neurophysiological and Functional Difference With Natural Lefthanders
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University Hospital, Ghent
- Enrollment
- 82
- Locations
- 1
- Primary Endpoint
- Sensibility hand
Study Overview
Brief Summary
The aim of the project is to assess the neurophysiological and functional consequences of forced lefthandedness in a population with right neonatal brachial plexus palsy (NBPP).
Detailed Description
A cross-sectional case-control study design to assess the neurophysiological and functional consequences of forced lefthandedness in a population with right neonatal brachial plexus palsy (NBPP). Controls are natural lefthanded typical developing children and adolescents.Case and controls are matched for age, gender and activity level.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 6 Years to 23 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •typical developing
- •lefthanded
- •NBPP or healthy
- •righthanded parents
- •6-23 years
Exclusion Criteria
- •history of other locomotor or neurological disorder than NBPP
- •history of brain surgery
- •history of psychiatric disorder
Outcomes
Primary Outcomes
Sensibility hand
Time Frame: Baseline
Semmes-Weinstein monofilament ( normal- abnormal)
Baseline measure : brain imaging
Time Frame: Baseline
Magnetic resonance imaging (MRI)
Strength-3
Time Frame: Baseline
Active Movement scale (AMS): score 0-7 ; 0: no contraction to 7 : full motion
Strength-1
Time Frame: Baseline
Medical Research Council Scale (MRC-scale) : score 0-5 ; 0 : no muscle contraction (worse) to 5 : normal power (better)
Strength-2
Time Frame: Baseline
Grip Strength (E-link) : Percent of the norm : higher = better
Handedness
Time Frame: Baseline
Edinburgh Handedness Inventory (EDI) : Lateralization index: -100 (pure lefthander) to +100 (pure righthander)
Baseline measure : movement pattern
Time Frame: Baseline
Kinematic movement analysis (kinematic angels, kinetic forces, movement patterns)
Body representation
Time Frame: Baseline
actual, implicit hand representation by drawings : mm
Secondary Outcomes
- Function( for cases)(Baseline)
- muscle and nerve function(baseline)
- Activity-1(Baseline)
- quality of life-1(Baseline)
- quality of life-2(Baseline)
- cognition(baseline)
- Activity-2(Baseline)
- Activity-4(Baseline)
- Activity-3(Baseline)
- shoulder function cases(Baseline)
- writing(baseline)